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Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3

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Detalhes bibliográficos
Resumo:Mechanisms of acquired protection to malaria in asymptomatic Plasmodium falciparum carriers are only partially understood. Among them, the role plays by the self-reactive antibodies has not been clarified yet. In this study, the relationship between repertoires of circulating self-reactive and parasite-specific immunoglobulin G (IgG), their correlation with cytokine levels, and their association with protection against malaria was investigated in asymptomatic Plasmodium falciparum-infected Gabonese children.
Autores principais:Guiyedi, Vincent
Outros Autores:Bécavin, Christophe; Herbert, Fabien; Gray, Julian; Cazenave, Pierre-André; Kombila, Maryvonne; Crisanti, Andrea; Fesel, Constantin; Pied, Sylviane
Assunto:Auto-antibody Antibody response Plasmodium falciparum Malaria Cytokines
Ano:2015
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Repositório do GIMM – Gulbenkian Institute for Molecular Medicine
Idioma:inglês
Origem:ARCA

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