Publicação

Microbiota Control of Malaria Transmission

Detalhes bibliográficos
Resumo:	Stable mutualistic interactions between multicellular organisms and microbes are an evolutionarily conserved process with a major impact on host physiology and fitness. Humans establish such interactions with a consortium of microorganisms known as the microbiota. Despite the mutualistic nature of these interactions, some bacterial components of the human microbiota express immunogenic glycans that elicit glycan-specific antibody (Ab) responses. The ensuing circulating Abs are protective against infections by pathogens that express those glycans, as demonstrated for Plasmodium, the causative agent of malaria. Presumably, a similar protective Ab response acts against other vector-borne diseases.
Autores principais:	Soares, Miguel P.
Outros Autores:	Yilmaz, Bahtiyar
Assunto:	Antibodies Biological Evolution Host-Pathogen Interactions Humans Intestines Malaria, Falciparum Microbiota Plasmodium falciparum Polysaccharides Protozoan Vaccines
Ano:	2016
País:	Portugal
Tipo de documento:	artigo
Tipo de acesso:	acesso aberto
Instituição associada:	Repositório do GIMM – Gulbenkian Institute for Molecular Medicine
Idioma:	inglês
Origem:	ARCA

Descrição
Resumo:	Stable mutualistic interactions between multicellular organisms and microbes are an evolutionarily conserved process with a major impact on host physiology and fitness. Humans establish such interactions with a consortium of microorganisms known as the microbiota. Despite the mutualistic nature of these interactions, some bacterial components of the human microbiota express immunogenic glycans that elicit glycan-specific antibody (Ab) responses. The ensuing circulating Abs are protective against infections by pathogens that express those glycans, as demonstrated for Plasmodium, the causative agent of malaria. Presumably, a similar protective Ab response acts against other vector-borne diseases.

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