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Synthesis and characterization of molecularly imprinted polymer particles (MIPs) for biomedical applications

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Resumo:In this work the synthesis of Molecularly Imprinted Polymers (MIPs) was made us-ing different techniques of polymerization, such as, in solution (micro-reactor and batch reactor) and inverse suspension, aiming the study of the effect of synthesis conditions on the properties and performance of materials obtained. The mechanisms used in the reactions were: free radical polymerization (FRP) and chain transfer polymerization by reversible addition-fragmentation (RAFT). For the production of the MIPs were used as base monomers the acrylic acid (AA), methacrylic acid (MAA) and N-isopropylacrylamide (NIPA) and as target molecules the 5-fluorouracil (5FU, used in the treatment of cancer) and caffeine (CAF, stimulant of the central nervous system). The characterization of the MIPs was made by two quantitative methods, solid phase extraction (SPE) with subsequent analysis through ultraviolet (UV) spectroscopy, and frontal analysis using a gel permeation chromatography (GPC) system, in order to evalu-ate the adsorption (saturation) and desorption (release) of molecules considered. The obtained particles were also analyzed by scanning electron microscopy (SEM). It was concluded that the combination of different synthesis tools (molecular im-printing/controlled radical polymerization) can be used to produce polymer particles with applications in molecular recognition and controlled drug delivery.
Autores principais:Freitas, Ana Filipa Fernandes Lobo
Assunto:5-Fluorouracil Caffeine Molecularly imprinted polymers Molecular recognition
Ano:2015
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso aberto
Instituição associada:Instituto Politécnico de Bragança
Idioma:inglês
Origem:Biblioteca Digital do IPB

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