Publicação
Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination
| Resumo: | Echocardiography is a reliable and non-invasive method for assessing cardiac structure and function in both clinical and experimental settings, offering valuable insights into disease progression and treatment efficacy. The successful application of echocardiography in murine models of disease has enabled the evaluation of disease severity, drug testing, and continuous monitoring of cardiac function in these animals. However, there is insufficient standardization of echocardiographic measurements for smaller animals. This article aims to address this gap by providing a guide and practical tips for the appropriate acquisition and analysis of echocardiographic parameters in adult rats, which may also be applicable in other small rodents used for scientific purposes, like mice. With advancements in technology, such as ultrahigh-frequency ultrasonic transducers, echocardiography has become a highly sophisticated imaging modality, offering high temporal and spatial resolution imaging, thereby allowing for real-time monitoring of cardiac function throughout the lifespan of small animals. Moreover, it allows the assessment of cardiac complications associated with aging, cancer, diabetes, and obesity, as well as the monitoring of cardiotoxicity induced by therapeutic interventions in preclinical models, providing important information for translational research. Finally, this paper discusses the future directions of cardiac preclinical ultrasound, highlighting the need for continued standardization to advance research and improve clinical outcomes to facilitate early disease detection and the translation of findings into clinical practice. |
|---|---|
| Autores principais: | Silva, Jessica |
| Outros Autores: | Ginja, Mário; Oliveira, Paula A.; Duarte, José Alberto; Faustino-Rocha, Ana |
| Assunto: | Echocardiography Murine models Heart function |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172755920650240 |
|---|---|
| author | Silva, Jessica |
| author2 | Ginja, Mário Oliveira, Paula A. Duarte, José Alberto Faustino-Rocha, Ana |
| author2_role | author author author author |
| author_facet | Silva, Jessica Ginja, Mário Oliveira, Paula A. Duarte, José Alberto Faustino-Rocha, Ana |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Silva, Jessica\"},{\"Person.name\":\"Ginja, Mário\"},{\"Person.name\":\"Oliveira, Paula A.\"},{\"Person.name\":\"Duarte, José Alberto\"},{\"Person.name\":\"Faustino-Rocha, Ana\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Silva, Jessica Ginja, Mário Oliveira, Paula A. Duarte, José Alberto Faustino-Rocha, Ana |
| datacite.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-10-21T13:33:43Z |
| datacite.date.embargoed.fl_str_mv | 2024-10-21T13:33:43Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Echocardiography Murine models Heart function |
| datacite.titles.title.fl_str_mv | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Silva, Jessica Ginja, Mário Oliveira, Paula A. Duarte, José Alberto Faustino-Rocha, Ana |
| dc.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-10-21T13:33:43Z |
| dc.date.embargoed.fl_str_mv | 2024-10-21T13:33:43Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/30464 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Echocardiography Murine models Heart function |
| dc.title.fl_str_mv | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Echocardiography is a reliable and non-invasive method for assessing cardiac structure and function in both clinical and experimental settings, offering valuable insights into disease progression and treatment efficacy. The successful application of echocardiography in murine models of disease has enabled the evaluation of disease severity, drug testing, and continuous monitoring of cardiac function in these animals. However, there is insufficient standardization of echocardiographic measurements for smaller animals. This article aims to address this gap by providing a guide and practical tips for the appropriate acquisition and analysis of echocardiographic parameters in adult rats, which may also be applicable in other small rodents used for scientific purposes, like mice. With advancements in technology, such as ultrahigh-frequency ultrasonic transducers, echocardiography has become a highly sophisticated imaging modality, offering high temporal and spatial resolution imaging, thereby allowing for real-time monitoring of cardiac function throughout the lifespan of small animals. Moreover, it allows the assessment of cardiac complications associated with aging, cancer, diabetes, and obesity, as well as the monitoring of cardiotoxicity induced by therapeutic interventions in preclinical models, providing important information for translational research. Finally, this paper discusses the future directions of cardiac preclinical ultrasound, highlighting the need for continued standardization to advance research and improve clinical outcomes to facilitate early disease detection and the translation of findings into clinical practice. |
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| eu_rights_str_mv | openAccess |
| format | article |
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| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
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| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Silva, Jessica Ginja, Mário Oliveira, Paula A. Duarte, José Alberto Faustino-Rocha, Ana |
| publishDate | 2024 |
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| spelling | engMDPIpt_PTEchocardiography is a reliable and non-invasive method for assessing cardiac structure and function in both clinical and experimental settings, offering valuable insights into disease progression and treatment efficacy. The successful application of echocardiography in murine models of disease has enabled the evaluation of disease severity, drug testing, and continuous monitoring of cardiac function in these animals. However, there is insufficient standardization of echocardiographic measurements for smaller animals. This article aims to address this gap by providing a guide and practical tips for the appropriate acquisition and analysis of echocardiographic parameters in adult rats, which may also be applicable in other small rodents used for scientific purposes, like mice. With advancements in technology, such as ultrahigh-frequency ultrasonic transducers, echocardiography has become a highly sophisticated imaging modality, offering high temporal and spatial resolution imaging, thereby allowing for real-time monitoring of cardiac function throughout the lifespan of small animals. Moreover, it allows the assessment of cardiac complications associated with aging, cancer, diabetes, and obesity, as well as the monitoring of cardiotoxicity induced by therapeutic interventions in preclinical models, providing important information for translational research. Finally, this paper discusses the future directions of cardiac preclinical ultrasound, highlighting the need for continued standardization to advance research and improve clinical outcomes to facilitate early disease detection and the translation of findings into clinical practice.application/pdfpt_PTRealistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved ExaminationSilva, JessicaGinja, MárioOliveira, Paula A.Duarte, José AlbertoFaustino-Rocha, AnaHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf2313-433XDOIIsPartOf10.3390/jimaging100902192024-10-21T13:33:43Z20242024-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/30464http://purl.org/coar/access_right/c_abf2open accessEchocardiographyMurine modelsHeart function4293635 bytesFundação para a Ciência e a TecnologiaCentre for the Research and Technology of Agro-Environmental and Biological Sciences6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaInstitute for innovation, capacity building and sustainability of agri-food production6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaVeterinary and Animal Science Research Centre6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaAssociate Laboratory for Animal and Veterinary Sciences6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaMountain Research Center6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaMountain Research Center6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaAssociate Laboratory for Sustainability and Tecnology in Mountain Regions6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2024http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/449fee33-6510-40c2-b135-57be64a83b2e/downloadJournal of Imaging109131 |
| spellingShingle | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination Silva, Jessica Echocardiography Murine models Heart function |
| status | SINGLETON |
| subject.fl_str_mv | Echocardiography Murine models Heart function |
| title | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination |
| title_full | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination |
| title_fullStr | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination |
| title_full_unstemmed | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination |
| title_short | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination |
| title_sort | Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination |
| topic | Echocardiography Murine models Heart function |
| topic_facet | Echocardiography Murine models Heart function |
| url | http://hdl.handle.net/10198/30464 |
| visible | 1 |