Publicação
Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols
| Resumo: | Polyphenols have been attracting a growing interest by pharmaceutical, biomedical, cosmetic and food industries due to their proven beneficial effects on human health (e.g. antioxidant and anti-inflammatory effects with positive impact on protection of the cardiovascular system, cancer prevention or anti-aging actions). However, an effective bioavailability is an important practical issue. Failing to achieve it leads to no visible benefits of their use. Indeed, fast degradation in common conditions (owing to high sensitivity to temperature, pH and light), poor solubility in biological fluids and high metabolic and secretion rates are some well-known processes limiting polyphenols impact [1]. Thus, the development of vehicles aiming at stabilizing and protecting polyphenols from degradation, also allowing their sustained release, is a key issue to improve the effectiveness of such compounds. In this research, we explore RAFT polymerization to develop tailored materials useful as vehicles for the uptake and release of polyphenols. The preparation and testing of polymersomes based on RAFT-synthetized amphiphilic block copolymers and the generation of hybrid natural/synthetic materials, namely through the RAFT-mediated grafting of synthetic polymers on cellulose, are two different approaches here reported. |
|---|---|
| Autores principais: | Gomes, Catarina |
| Outros Autores: | Dias, Rolando; Costa, Mário Rui |
| Assunto: | RAFT polymerization Polymersomes Cellulose based materials Grafting Encapsulation Polyphenols |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172780655509504 |
|---|---|
| author | Gomes, Catarina |
| author2 | Dias, Rolando Costa, Mário Rui |
| author2_role | author author |
| author_facet | Gomes, Catarina Dias, Rolando Costa, Mário Rui |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Gomes, Catarina\",\"Person.identifier.orcid\":\"0000-0003-3396-3615\"},{\"Person.name\":\"Dias, Rolando\",\"Person.identifier.orcid\":\"0000-0001-7369-382X\"},{\"Person.name\":\"Costa, Mário Rui\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Gomes, Catarina Dias, Rolando Costa, Mário Rui |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-10-10T13:31:25Z |
| datacite.date.embargoed.fl_str_mv | 2018-10-10T13:31:25Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | RAFT polymerization Polymersomes Cellulose based materials Grafting Encapsulation Polyphenols |
| datacite.titles.title.fl_str_mv | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Gomes, Catarina Dias, Rolando Costa, Mário Rui |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-10-10T13:31:25Z |
| dc.date.embargoed.fl_str_mv | 2018-10-10T13:31:25Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/18038 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | RAFT polymerization Polymersomes Cellulose based materials Grafting Encapsulation Polyphenols |
| dc.title.fl_str_mv | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_c94f |
| description | Polyphenols have been attracting a growing interest by pharmaceutical, biomedical, cosmetic and food industries due to their proven beneficial effects on human health (e.g. antioxidant and anti-inflammatory effects with positive impact on protection of the cardiovascular system, cancer prevention or anti-aging actions). However, an effective bioavailability is an important practical issue. Failing to achieve it leads to no visible benefits of their use. Indeed, fast degradation in common conditions (owing to high sensitivity to temperature, pH and light), poor solubility in biological fluids and high metabolic and secretion rates are some well-known processes limiting polyphenols impact [1]. Thus, the development of vehicles aiming at stabilizing and protecting polyphenols from degradation, also allowing their sustained release, is a key issue to improve the effectiveness of such compounds. In this research, we explore RAFT polymerization to develop tailored materials useful as vehicles for the uptake and release of polyphenols. The preparation and testing of polymersomes based on RAFT-synthetized amphiphilic block copolymers and the generation of hybrid natural/synthetic materials, namely through the RAFT-mediated grafting of synthetic polymers on cellulose, are two different approaches here reported. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferenceObject |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/04523d36-2961-4f4a-b1f7-a951be3fdf89/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/18038 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/18038 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Gomes, Catarina Gomes, Catarina https://www.ciencia-id.pt/2B12-75A1-B8FB 2B12-75A1-B8FB http://orcid.org/0000-0003-3396-3615 0000-0003-3396-3615 Dias, Rolando Dias, Rolando https://www.ciencia-id.pt/8417-4D84-973B 8417-4D84-973B http://orcid.org/0000-0001-7369-382X 0000-0001-7369-382X Costa, Mário Rui |
| publishDate | 2018 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engpt_PTPolyphenols have been attracting a growing interest by pharmaceutical, biomedical, cosmetic and food industries due to their proven beneficial effects on human health (e.g. antioxidant and anti-inflammatory effects with positive impact on protection of the cardiovascular system, cancer prevention or anti-aging actions). However, an effective bioavailability is an important practical issue. Failing to achieve it leads to no visible benefits of their use. Indeed, fast degradation in common conditions (owing to high sensitivity to temperature, pH and light), poor solubility in biological fluids and high metabolic and secretion rates are some well-known processes limiting polyphenols impact [1]. Thus, the development of vehicles aiming at stabilizing and protecting polyphenols from degradation, also allowing their sustained release, is a key issue to improve the effectiveness of such compounds. In this research, we explore RAFT polymerization to develop tailored materials useful as vehicles for the uptake and release of polyphenols. The preparation and testing of polymersomes based on RAFT-synthetized amphiphilic block copolymers and the generation of hybrid natural/synthetic materials, namely through the RAFT-mediated grafting of synthetic polymers on cellulose, are two different approaches here reported.application/pdfpt_PTExploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenolsPersonalGomes, CatarinaDSpacehttp://dspace.org/items/eeffa916-1197-416e-a4fd-22281823df55DSpacehttp://dspace.org/items/eeffa916-1197-416e-a4fd-22281823df55GomesCatarina P.Ciência IDhttps://www.ciencia-id.pt2B12-75A1-B8FBORCIDhttp://orcid.org0000-0003-3396-3615Scopus Author IDhttps://www.scopus.com57190981477Scopus Author IDhttps://www.scopus.com57192206476PersonalDias, RolandoDSpacehttp://dspace.org/items/d7109687-6adf-4268-a462-8d1a2e2c01cbDSpacehttp://dspace.org/items/d7109687-6adf-4268-a462-8d1a2e2c01cbDiasRolandoCiência IDhttps://www.ciencia-id.pt8417-4D84-973BORCIDhttp://orcid.org0000-0001-7369-382XResearcher IDhttps://www.researcherid.comM-8552-2013Scopus Author IDhttps://www.scopus.com7102885104Costa, Mário RuiHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.pt2018-10-10T13:31:25Z20182018-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/18038http://purl.org/coar/access_right/c_abf2open accessRAFT polymerizationPolymersomesCellulose based materialsGraftingEncapsulationPolyphenols1934129 bytesother research producthttp://purl.org/coar/resource_type/c_c94fconference object2018http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/04523d36-2961-4f4a-b1f7-a951be3fdf89/download10th ECNP International Conference on Nanostructured Polymers and NanocompositesO19O19San Sebastian, Spain |
| spellingShingle | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols Gomes, Catarina RAFT polymerization Polymersomes Cellulose based materials Grafting Encapsulation Polyphenols |
| status | SINGLETON |
| subject.fl_str_mv | RAFT polymerization Polymersomes Cellulose based materials Grafting Encapsulation Polyphenols |
| title | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols |
| title_full | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols |
| title_fullStr | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols |
| title_full_unstemmed | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols |
| title_short | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols |
| title_sort | Exploiting RAFT polymerization to tailor vehicles for uptake and release of polyphenols |
| topic | RAFT polymerization Polymersomes Cellulose based materials Grafting Encapsulation Polyphenols |
| topic_facet | RAFT polymerization Polymersomes Cellulose based materials Grafting Encapsulation Polyphenols |
| url | http://hdl.handle.net/10198/18038 |
| visible | 1 |