Publicação
Evaluating the impact of using natural fixative agents as alternatives to formaldehyde in histopathology: a systematic review
| Resumo: | The histological technique involves several steps to prepare tissues for microscopic analysis, with fixation being one of the key steps. Formaldehyde is the most used fixing agent; however, it poses significant health risks and is classified as a Group 1 human carcinogen by the IARC and the NTP. This concern has prompted the search for safer alternatives. This study aims to identify a less harmful natural substitute for formaldehyde that can reduce or eliminate exposure to this hazardous reagent. To achieve this objective, a systematic review explored the potential of natural fixatives that can perform similar functions with lower toxicity. |
|---|---|
| Autores principais: | Horta, Andreia |
| Outros Autores: | Condesso, Nádia; Maia-Matos, Mário; Borges-Ferro, A |
| Assunto: | Histopathology Formaldehyde Natural fixative agents Toxicity Systematic review |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | póster em conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Científico do Instituto Politécnico de Lisboa |
| Resumo: | The histological technique involves several steps to prepare tissues for microscopic analysis, with fixation being one of the key steps. Formaldehyde is the most used fixing agent; however, it poses significant health risks and is classified as a Group 1 human carcinogen by the IARC and the NTP. This concern has prompted the search for safer alternatives. This study aims to identify a less harmful natural substitute for formaldehyde that can reduce or eliminate exposure to this hazardous reagent. To achieve this objective, a systematic review explored the potential of natural fixatives that can perform similar functions with lower toxicity. |
|---|