Publicação
An enzymatic route to a benzocarbazole framework using bacterial CotA laccase
| Resumo: | The CotA laccase-catalysed oxidation of the meta, para-disubstituted arylamine 2,4-diaminophenyldiamine delivers, under mild reaction conditions, a benzocarbazole derivative (1) (74% yield), a key structural motif of a diverse range of applications. This work extends the scope of aromatic frameworks obtained using these enzymes and represents a new efficient and clean method to construct in one step C-C and C-N bonds. |
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| Autores principais: | Sousa, Ana Catarina |
| Outros Autores: | Piedade, Maria de Fátima M. M.; Martins, Lígia O.; Robalo, Maria Paula |
| Assunto: | Active carbazole alkaloids Transition-Metal-Complexes Organic-Synthesis Fungal laccases Antimicrobial activity Biological evaluation Coupling reactions Bacillus-subtilis Domino reactions Green chemistry |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Instituto Politécnico de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Científico do Instituto Politécnico de Lisboa |
| Resumo: | The CotA laccase-catalysed oxidation of the meta, para-disubstituted arylamine 2,4-diaminophenyldiamine delivers, under mild reaction conditions, a benzocarbazole derivative (1) (74% yield), a key structural motif of a diverse range of applications. This work extends the scope of aromatic frameworks obtained using these enzymes and represents a new efficient and clean method to construct in one step C-C and C-N bonds. |
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