Detalhes bibliográficos
| Resumo: | We have identified an allelic deletion common region in the q26 region of chromosome 10 in endometrial carcinomas, which has been reported previously as a potential target of genetic alterations related to this neoplasia. An allelotyping analysis of 19 pairs of tumoral and non-tumoral samples was accomplished using seven microsatellite polymorphic markers mapping in the 10q26 chromosomal region. Loss of heterozygosity for one or more loci was detected in 29% of the endometrial carcinoma samples. The observed pattern of loss enabled the identification of a 3.5 Mb common deleted region located between the D10S587 and D10S186 markers. An additional result from an endometrial sample with evidence of a RER phenotype may suggest a more centromeric region of loss within the above-mentioned interval. This 401.84 Kb interval flanked by the D10S587 and D10S216 markers may be a plausible location for a putative suppressor gene involved in early stage endometrial carcinogenesis. |
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| Autores principais: | Alves, Margarida |
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| Outros Autores: | Carreira, Isabel; Liberato, Paulo; Ramos, Sância; Mafra, Manuela; Inverno, Alexandra S.; Maia, Ana T.; Martins, Ana Paula; Brito, Miguel; Monteiro, Carolino |
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| Assunto: | Carcinoma Chromosome deletion Chromosome mapping DNA mutational analysis DNA replication Endometrial neoplasms Genetic linkage Loss of heterozygosity Matched-Pair analysis Microsatellite instability |
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| Ano: | 2010 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Instituto Politécnico de Lisboa |
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| Idioma: | inglês |
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| Origem: | Repositório Científico do Instituto Politécnico de Lisboa |
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