Publicação
Blood molecular profile to predict genotoxicity from exposure to antineoplastic drugs: a comparison with cytokinesis-block micronucleus assay results
| Resumo: | Genotoxicity is an important information that should be included in human biomonitoring programs design. Cytogenetic methods are usually laborious and time-consuming; therefore, the development of new molecular methods is an added value. This study aimed to evaluate if the molecular profile of previously frozen whole blood acquired by Fourier Transform Infrared (FTIR) spectroscopy allows for to assessment of genotoxicity in occupational exposure to antineoplastic drugs in hospital professionals, as obtained by the lymphocyte cytokinesis block micronucleus (CBMN) assay. |
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| Autores principais: | Ladeira, Carina |
| Outros Autores: | Araújo, Rúben; Ramalhete, Luís; Teixeira, Hélder; Calado, Cecília R. C. |
| Assunto: | Molecular profile FTIR-spectroscopy Genotoxicity Cytokinesis-blocked micronucleus assay Frozen blood Antineoplastics IDI&CA/IPL/2017/GenTox/ESTeSL FCT_DSAIPA/DS/0117/2020 ACT_036APJ/09 |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | póster em conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Científico do Instituto Politécnico de Lisboa |
| Resumo: | Genotoxicity is an important information that should be included in human biomonitoring programs design. Cytogenetic methods are usually laborious and time-consuming; therefore, the development of new molecular methods is an added value. This study aimed to evaluate if the molecular profile of previously frozen whole blood acquired by Fourier Transform Infrared (FTIR) spectroscopy allows for to assessment of genotoxicity in occupational exposure to antineoplastic drugs in hospital professionals, as obtained by the lymphocyte cytokinesis block micronucleus (CBMN) assay. |
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