Publicação
Optical Biosensing Platform for Detection of Antimicrobial Resistance
| Resumo: | Antimicrobial resistance (AMR) is a growing global health challenge, reinforcing the urgent need for rapid and sensitive diagnostic tools. This project aims to develop an optical-electronic system for the detection of specific AMR markers by integrating biosensing elements with an optical signal readout. The system will detect AMR-related targets through a biochemical recognition event that produces an optical signal, which will be quantified by a photodetector-based electronic circuit for real-time acquisition and processing. The device will be designed for high sensitivity, reliability, and ease of use, with a focus on point-of-care applications. The work will involve the selection and characterisation of optical and electronic components, design of the detection circuitry, optical alignment, signal processing, development of the detection protocol, and validation using target sequences of AMR genes. The expected outcome is a functional biosensing system, with high sensitivity, that demonstrates the feasibility of using integrated optical and electronic technologies for AMR diagnostics, contributing to more efficient and decentralised detection strategies. |
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| Autores principais: | Oliveira, F. |
| Outros Autores: | Nogueira, C.; Catarino, Susana Oliveira; Carvalho, C. |
| Assunto: | Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática Saúde de qualidade |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Antimicrobial resistance (AMR) is a growing global health challenge, reinforcing the urgent need for rapid and sensitive diagnostic tools. This project aims to develop an optical-electronic system for the detection of specific AMR markers by integrating biosensing elements with an optical signal readout. The system will detect AMR-related targets through a biochemical recognition event that produces an optical signal, which will be quantified by a photodetector-based electronic circuit for real-time acquisition and processing. The device will be designed for high sensitivity, reliability, and ease of use, with a focus on point-of-care applications. The work will involve the selection and characterisation of optical and electronic components, design of the detection circuitry, optical alignment, signal processing, development of the detection protocol, and validation using target sequences of AMR genes. The expected outcome is a functional biosensing system, with high sensitivity, that demonstrates the feasibility of using integrated optical and electronic technologies for AMR diagnostics, contributing to more efficient and decentralised detection strategies. |
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