Publicação
Photorelease of glycine and β-alanine from (7-bromocoumarin-4-yl)methyl cages
| Resumo: | With the goal of evaluating the efficiency of 4-chloromethyl-7-bromocoumarin as phototrigger for amino acid neurotransmitters glycine and β-alanine, the corresponding ester conjugates were synthetized. Their irradiation at different wavelengths (254, 300, 350 and 419 nm) in a Rayonet RPR-100 photochemical reactor, in methanol/HEPES buffer (80:20) was carried out. The photolysis process was followed by HPLC with UV detection. Results will be discussed in comparison with those obtained when 4-chloromethyl-7-aminocoumarin was used in the photorelease of glycine and β-alanine. |
|---|---|
| Autores principais: | Conceição, Rafaela C. O. |
| Outros Autores: | Costa, Susana P. G.; Gonçalves, M. Sameiro T. |
| Assunto: | Photolysis Beta-alanine Coumarin Glycine Ciências Naturais::Ciências Químicas |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | With the goal of evaluating the efficiency of 4-chloromethyl-7-bromocoumarin as phototrigger for amino acid neurotransmitters glycine and β-alanine, the corresponding ester conjugates were synthetized. Their irradiation at different wavelengths (254, 300, 350 and 419 nm) in a Rayonet RPR-100 photochemical reactor, in methanol/HEPES buffer (80:20) was carried out. The photolysis process was followed by HPLC with UV detection. Results will be discussed in comparison with those obtained when 4-chloromethyl-7-aminocoumarin was used in the photorelease of glycine and β-alanine. |
|---|