Publicação
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
| Resumo: | We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line. |
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| Autores principais: | Sá, Arsénio Vasconcelos |
| Outros Autores: | Matias, Áurea A.; Prata, M. Isabel M.; Geraldes, Carlos F. G. C.; Ferreira, Paula M. T.; André, João P. |
| Assunto: | Triaza Orthogonal protection Bifunctional chelators Gallium Radiopharmacy Integrin αѵβ₃receptor Integrin alpha(v)beta(3) receptor Integrin a ß receptor ? 3 Integrin α β receptor ν 3 |
| Ano: | 2010 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line. |
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