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Investigation of different hydrogels for nucleus replacement : a biomechanical study

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Detalhes bibliográficos
Resumo:Hydrogels are considered promising for disc regeneration strategies. However, it is currently unknown whether the destruction of the natural interface between nucleus and surrounding structures caused by nucleotomy and an inadequate annulus closure diminishes the mechanical competence of the disc. To clarify these mechanisms and to evaluate whether hydrogels are able to restore the biomechanical behaviour of the disc a combined in vivo and in vitro and approach was used.
Autores principais:Reitmaier, Sandra
Outros Autores:Wolfram, Uwe; Ignatius, Anita; Wilke, Hans-Joachim; Martín-Martínez, José M.; Silva-Correia, Joana; Oliveira, Joaquim M.; Reis, R. L.; Schmidt, Hendrik
Assunto:Hydrogels IVD
Ano:2012
País:Portugal
Tipo de documento:outro
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:Hydrogels are considered promising for disc regeneration strategies. However, it is currently unknown whether the destruction of the natural interface between nucleus and surrounding structures caused by nucleotomy and an inadequate annulus closure diminishes the mechanical competence of the disc. To clarify these mechanisms and to evaluate whether hydrogels are able to restore the biomechanical behaviour of the disc a combined in vivo and in vitro and approach was used.