Publicação
Drug targeting of inflammatory bowel diseases by biomolecules
| Resumo: | Inflammatory bowel disease (IBD) is a group of disabling, destructive and incurable immune-mediated inflammatory diseases comprising Crohn's disease (CD) and ulcerative colitis (UC), disorders that are highly prevalent worldwide and demand a large investment in healthcare. A persistent inflammatory state enables the dysfunction and destruction of healthy tissue, hindering the initiation and endurance of wound healing. Current treatments are ineffective at counteracting disease progression. Further, increased risk of serious side effects, other comorbidities and/or opportunistic infections highlight the need for effective treatment options. Gut microbiota, the key to preserving a healthy state, may, alternatively, increase a patient's susceptibility to IBD onset and development given a relevant bacterial dysbiosis. Hence, the main goal of this review is to showcase the main conventional and emerging therapies for IBD, including microbiota-inspired untargeted and targeted approaches (such as phage therapy) to infection control. Special recognition is given to existing targeted strategies with biologics (via monoclonal antibodies, small molecules and nucleic acids) and stimuli-responsive (pH-, enzyme- and reactive oxygen species-triggered release), polymer-based nanomedicine that is specifically directed towards the regulation of inflammation overload (with some nanosystems additionally functionalized with carbohydrates or peptides directed towards M1-macrophages). The overall goal is to restore gut balance and decrease IBD's societal impact. |
|---|---|
| Autores principais: | Antunes, Joana Isabel Costa |
| Outros Autores: | Seabra, Catarina Leal; Domingues, Joana Margarida; Teixeira, Marta Oliveira; Nunes, Cláudia; Costa-Lima, Sofia Antunes; Homem, Natália Cândido; Reis, Salette; Amorim, M. T. Pessoa de; Felgueiras, Helena Prado |
| Assunto: | Biologics Gut dysbiosis Infection Microbiota Crohn’s disease Ulcerative colitis Treatment Polymeric nanoparticles Engenharia e Tecnologia::Engenharia Médica |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438251263918080 |
|---|---|
| author | Antunes, Joana Isabel Costa |
| author2 | Seabra, Catarina Leal Domingues, Joana Margarida Teixeira, Marta Oliveira Nunes, Cláudia Costa-Lima, Sofia Antunes Homem, Natália Cândido Reis, Salette Amorim, M. T. Pessoa de Felgueiras, Helena Prado |
| author2_role | author author author author author author author author author |
| author_facet | Antunes, Joana Isabel Costa Seabra, Catarina Leal Domingues, Joana Margarida Teixeira, Marta Oliveira Nunes, Cláudia Costa-Lima, Sofia Antunes Homem, Natália Cândido Reis, Salette Amorim, M. T. Pessoa de Felgueiras, Helena Prado |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Antunes, Joana Isabel Costa\"},{\"Person.name\":\"Seabra, Catarina Leal\"},{\"Person.name\":\"Domingues, Joana Margarida\"},{\"Person.name\":\"Teixeira, Marta Oliveira\"},{\"Person.name\":\"Nunes, Cláudia\"},{\"Person.name\":\"Costa-Lima, Sofia Antunes\"},{\"Person.name\":\"Homem, Natália Cândido\"},{\"Person.name\":\"Reis, Salette\"},{\"Person.name\":\"Amorim, M. T. Pessoa de\"},{\"Person.name\":\"Felgueiras, Helena Prado\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Antunes, Joana Isabel Costa Seabra, Catarina Leal Domingues, Joana Margarida Teixeira, Marta Oliveira Nunes, Cláudia Costa-Lima, Sofia Antunes Homem, Natália Cândido Reis, Salette Amorim, M. T. Pessoa de Felgueiras, Helena Prado |
| datacite.date.Accepted.fl_str_mv | 2021-08-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-09-27T09:44:54Z |
| datacite.date.embargoed.fl_str_mv | 2021-09-27T09:44:54Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Biologics Gut dysbiosis Infection Microbiota Crohn’s disease Ulcerative colitis Treatment Polymeric nanoparticles Engenharia e Tecnologia::Engenharia Médica |
| datacite.titles.title.fl_str_mv | Drug targeting of inflammatory bowel diseases by biomolecules |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Antunes, Joana Isabel Costa Seabra, Catarina Leal Domingues, Joana Margarida Teixeira, Marta Oliveira Nunes, Cláudia Costa-Lima, Sofia Antunes Homem, Natália Cândido Reis, Salette Amorim, M. T. Pessoa de Felgueiras, Helena Prado |
| dc.date.Accepted.fl_str_mv | 2021-08-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-09-27T09:44:54Z |
| dc.date.embargoed.fl_str_mv | 2021-09-27T09:44:54Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/74156 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Biologics Gut dysbiosis Infection Microbiota Crohn’s disease Ulcerative colitis Treatment Polymeric nanoparticles Engenharia e Tecnologia::Engenharia Médica |
| dc.title.fl_str_mv | Drug targeting of inflammatory bowel diseases by biomolecules |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Inflammatory bowel disease (IBD) is a group of disabling, destructive and incurable immune-mediated inflammatory diseases comprising Crohn's disease (CD) and ulcerative colitis (UC), disorders that are highly prevalent worldwide and demand a large investment in healthcare. A persistent inflammatory state enables the dysfunction and destruction of healthy tissue, hindering the initiation and endurance of wound healing. Current treatments are ineffective at counteracting disease progression. Further, increased risk of serious side effects, other comorbidities and/or opportunistic infections highlight the need for effective treatment options. Gut microbiota, the key to preserving a healthy state, may, alternatively, increase a patient's susceptibility to IBD onset and development given a relevant bacterial dysbiosis. Hence, the main goal of this review is to showcase the main conventional and emerging therapies for IBD, including microbiota-inspired untargeted and targeted approaches (such as phage therapy) to infection control. Special recognition is given to existing targeted strategies with biologics (via monoclonal antibodies, small molecules and nucleic acids) and stimuli-responsive (pH-, enzyme- and reactive oxygen species-triggered release), polymer-based nanomedicine that is specifically directed towards the regulation of inflammation overload (with some nanosystems additionally functionalized with carbohydrates or peptides directed towards M1-macrophages). The overall goal is to restore gut balance and decrease IBD's societal impact. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/231fdaa5-6cec-4edc-98b6-0067eb96553b/download |
| id | rum_4901adbedf17c9692ef4dcd034378b9e |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/74156 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/74156 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Antunes, Joana Isabel Costa Seabra, Catarina Leal Domingues, Joana Margarida Teixeira, Marta Oliveira Nunes, Cláudia Costa-Lima, Sofia Antunes Homem, Natália Cândido Reis, Salette Amorim, M. T. Pessoa de Felgueiras, Helena Prado |
| publishDate | 2021 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMDPIporInflammatory bowel disease (IBD) is a group of disabling, destructive and incurable immune-mediated inflammatory diseases comprising Crohn's disease (CD) and ulcerative colitis (UC), disorders that are highly prevalent worldwide and demand a large investment in healthcare. A persistent inflammatory state enables the dysfunction and destruction of healthy tissue, hindering the initiation and endurance of wound healing. Current treatments are ineffective at counteracting disease progression. Further, increased risk of serious side effects, other comorbidities and/or opportunistic infections highlight the need for effective treatment options. Gut microbiota, the key to preserving a healthy state, may, alternatively, increase a patient's susceptibility to IBD onset and development given a relevant bacterial dysbiosis. Hence, the main goal of this review is to showcase the main conventional and emerging therapies for IBD, including microbiota-inspired untargeted and targeted approaches (such as phage therapy) to infection control. Special recognition is given to existing targeted strategies with biologics (via monoclonal antibodies, small molecules and nucleic acids) and stimuli-responsive (pH-, enzyme- and reactive oxygen species-triggered release), polymer-based nanomedicine that is specifically directed towards the regulation of inflammation overload (with some nanosystems additionally functionalized with carbohydrates or peptides directed towards M1-macrophages). The overall goal is to restore gut balance and decrease IBD's societal impact.application/pdfporDrug targeting of inflammatory bowel diseases by biomoleculesAntunes, Joana Isabel CostaSeabra, Catarina LealDomingues, Joana MargaridaTeixeira, Marta OliveiraNunes, CláudiaCosta-Lima, Sofia AntunesHomem, Natália CândidoReis, SaletteAmorim, M. T. Pessoa deFelgueiras, Helena PradoHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONAntunes, J. C., Seabra, C. L., Domingues, J. M., Teixeira, M. O., Nunes, C., Costa-Lima, S. A., ... & Felgueiras, H. P. (2021). Drug Targeting of Inflammatory Bowel Diseases by Biomolecules. Nanomaterials, 11(8), 2035ISSNIsPartOf2079-4991DOIIsPartOf10.3390/nano110820352021-09-27T09:44:54Z2021-082021-062021-08-01T00:00:00ZHandlehttps://hdl.handle.net/1822/74156http://purl.org/coar/access_right/c_abf2open accessBiologicsGut dysbiosisInfectionMicrobiotaCrohn’s diseaseUlcerative colitisTreatmentPolymeric nanoparticleshttp://www.oecd.org/science/inno/38235147.pdfFields of Science and Technology (FOS)Engenharia e Tecnologia::Engenharia Médica1504919 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/231fdaa5-6cec-4edc-98b6-0067eb96553b/download |
| spellingShingle | Drug targeting of inflammatory bowel diseases by biomolecules Antunes, Joana Isabel Costa Biologics Gut dysbiosis Infection Microbiota Crohn’s disease Ulcerative colitis Treatment Polymeric nanoparticles Engenharia e Tecnologia::Engenharia Médica |
| status | SINGLETON |
| subject.fl_str_mv | Biologics Gut dysbiosis Infection Microbiota Crohn’s disease Ulcerative colitis Treatment Polymeric nanoparticles |
| subject.other.fl_str_mv | Engenharia e Tecnologia::Engenharia Médica |
| title | Drug targeting of inflammatory bowel diseases by biomolecules |
| title_full | Drug targeting of inflammatory bowel diseases by biomolecules |
| title_fullStr | Drug targeting of inflammatory bowel diseases by biomolecules |
| title_full_unstemmed | Drug targeting of inflammatory bowel diseases by biomolecules |
| title_short | Drug targeting of inflammatory bowel diseases by biomolecules |
| title_sort | Drug targeting of inflammatory bowel diseases by biomolecules |
| topic | Biologics Gut dysbiosis Infection Microbiota Crohn’s disease Ulcerative colitis Treatment Polymeric nanoparticles Engenharia e Tecnologia::Engenharia Médica |
| topic_facet | Biologics Gut dysbiosis Infection Microbiota Crohn’s disease Ulcerative colitis Treatment Polymeric nanoparticles Engenharia e Tecnologia::Engenharia Médica |
| url | https://hdl.handle.net/1822/74156 |
| visible | 1 |