Publicação
Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique
| Resumo: | Bovine tuberculosis is a zoonotic disease with largely unknown impact in Africa, with risk factors such as HIV and direct contact with animals or consumption of Mycobacterium bovis infected animal products. In order to understand and quantify this risk and design intervention strategies, good epidemiological studies are needed. Such studies can include molecular typing of M. bovis isolates. The aim of this study was to apply these tools to provide novel information concerning the distribution of bovine tuberculosis in cattle in Mozambique and thereby provide relevant information to guide policy development and strategies to contain the disease in livestock, and reduce the risk associated with transmission to humans. A collection of 178 M. bovis isolates was obtained from cattle in Mozambique. Using spoligotyping and regions of difference analysis, we classified the isolates into clonal complexes, thus reporting the first characterisation of M. bovis strains in this region. Data from MIRU-VNTR typing was used to compare isolates from a number of African countries, revealing a deeply geographically structured diversity of M. bovis. Eastern Africa appears to show high diversity, suggesting deep evolution in that region. The diversity of M. bovis in Africa does not seem to be a function of recent importation of animals, but is probably maintained within each particular region by constant reinfection from reservoir animals. Understanding the transmission routes of M. bovis in Mozambique and elsewhere is essential in order to focus public health and veterinary resources to contain bovine tuberculosis. |
|---|---|
| Autores principais: | Machado, Adelina |
| Outros Autores: | Rito, Teresa; Ghebremichael, Solomon; Muhate, Nuelma; Maxhuza, Gabriel; Macuamule, Custodia; Moiane, Ivania; Macucule, Baltazar; Marranangumbe, Angelica Suzana; Baptista, Jorge; Manguele, Joaquim; Koivula, Tuija; Streicher, Elizabeth Maria; Warren, Robin Mark; Kallenius, Gunilla; van Helden, Paul; Correia-Neves, M |
| Assunto: | Animals Cattle Genotype Molecular Epidemiology Molecular Typing Mozambique Mycobacterium bovis Tuberculosis, Bovine Zoonoses Disease Transmission, Infectious Genetic Variation Ciências Médicas::Medicina Básica |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867438063104294912 |
|---|---|
| author | Machado, Adelina |
| author2 | Rito, Teresa Ghebremichael, Solomon Muhate, Nuelma Maxhuza, Gabriel Macuamule, Custodia Moiane, Ivania Macucule, Baltazar Marranangumbe, Angelica Suzana Baptista, Jorge Manguele, Joaquim Koivula, Tuija Streicher, Elizabeth Maria Warren, Robin Mark Kallenius, Gunilla van Helden, Paul Correia-Neves, M |
| author2_role | author author author author author author author author author author author author author author author author |
| author_facet | Machado, Adelina Rito, Teresa Ghebremichael, Solomon Muhate, Nuelma Maxhuza, Gabriel Macuamule, Custodia Moiane, Ivania Macucule, Baltazar Marranangumbe, Angelica Suzana Baptista, Jorge Manguele, Joaquim Koivula, Tuija Streicher, Elizabeth Maria Warren, Robin Mark Kallenius, Gunilla van Helden, Paul Correia-Neves, M |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Machado, Adelina\"},{\"Person.name\":\"Rito, Teresa\"},{\"Person.name\":\"Ghebremichael, Solomon\"},{\"Person.name\":\"Muhate, Nuelma\"},{\"Person.name\":\"Maxhuza, Gabriel\"},{\"Person.name\":\"Macuamule, Custodia\"},{\"Person.name\":\"Moiane, Ivania\"},{\"Person.name\":\"Macucule, Baltazar\"},{\"Person.name\":\"Marranangumbe, Angelica Suzana\"},{\"Person.name\":\"Baptista, Jorge\"},{\"Person.name\":\"Manguele, Joaquim\"},{\"Person.name\":\"Koivula, Tuija\"},{\"Person.name\":\"Streicher, Elizabeth Maria\"},{\"Person.name\":\"Warren, Robin Mark\"},{\"Person.name\":\"Kallenius, Gunilla\"},{\"Person.name\":\"van Helden, Paul\"},{\"Person.name\":\"Correia-Neves, M\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Machado, Adelina Rito, Teresa Ghebremichael, Solomon Muhate, Nuelma Maxhuza, Gabriel Macuamule, Custodia Moiane, Ivania Macucule, Baltazar Marranangumbe, Angelica Suzana Baptista, Jorge Manguele, Joaquim Koivula, Tuija Streicher, Elizabeth Maria Warren, Robin Mark Kallenius, Gunilla van Helden, Paul Correia-Neves, M |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-01-07T16:15:40Z |
| datacite.date.embargoed.fl_str_mv | 2019-01-07T16:15:40Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Animals Cattle Genotype Molecular Epidemiology Molecular Typing Mozambique Mycobacterium bovis Tuberculosis, Bovine Zoonoses Disease Transmission, Infectious Genetic Variation Ciências Médicas::Medicina Básica |
| datacite.titles.title.fl_str_mv | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Machado, Adelina Rito, Teresa Ghebremichael, Solomon Muhate, Nuelma Maxhuza, Gabriel Macuamule, Custodia Moiane, Ivania Macucule, Baltazar Marranangumbe, Angelica Suzana Baptista, Jorge Manguele, Joaquim Koivula, Tuija Streicher, Elizabeth Maria Warren, Robin Mark Kallenius, Gunilla van Helden, Paul Correia-Neves, M |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-01-07T16:15:40Z |
| dc.date.embargoed.fl_str_mv | 2019-01-07T16:15:40Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/57875 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Public Library of Science (PLOS) |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Animals Cattle Genotype Molecular Epidemiology Molecular Typing Mozambique Mycobacterium bovis Tuberculosis, Bovine Zoonoses Disease Transmission, Infectious Genetic Variation Ciências Médicas::Medicina Básica |
| dc.title.fl_str_mv | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Bovine tuberculosis is a zoonotic disease with largely unknown impact in Africa, with risk factors such as HIV and direct contact with animals or consumption of Mycobacterium bovis infected animal products. In order to understand and quantify this risk and design intervention strategies, good epidemiological studies are needed. Such studies can include molecular typing of M. bovis isolates. The aim of this study was to apply these tools to provide novel information concerning the distribution of bovine tuberculosis in cattle in Mozambique and thereby provide relevant information to guide policy development and strategies to contain the disease in livestock, and reduce the risk associated with transmission to humans. A collection of 178 M. bovis isolates was obtained from cattle in Mozambique. Using spoligotyping and regions of difference analysis, we classified the isolates into clonal complexes, thus reporting the first characterisation of M. bovis strains in this region. Data from MIRU-VNTR typing was used to compare isolates from a number of African countries, revealing a deeply geographically structured diversity of M. bovis. Eastern Africa appears to show high diversity, suggesting deep evolution in that region. The diversity of M. bovis in Africa does not seem to be a function of recent importation of animals, but is probably maintained within each particular region by constant reinfection from reservoir animals. Understanding the transmission routes of M. bovis in Mozambique and elsewhere is essential in order to focus public health and veterinary resources to contain bovine tuberculosis. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/67985ee9-c456-47d1-ad27-e57b52c6deb8/download |
| id | rum_4d969a7d8a4332abdaafaa536bdd64bf |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/57875 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/57875 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Machado, Adelina Rito, Teresa Ghebremichael, Solomon Muhate, Nuelma Maxhuza, Gabriel Macuamule, Custodia Moiane, Ivania Macucule, Baltazar Marranangumbe, Angelica Suzana Baptista, Jorge Manguele, Joaquim Koivula, Tuija Streicher, Elizabeth Maria Warren, Robin Mark Kallenius, Gunilla van Helden, Paul Correia-Neves, M |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Public Library of Science (PLOS) |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engPublic Library of Science (PLOS)porBovine tuberculosis is a zoonotic disease with largely unknown impact in Africa, with risk factors such as HIV and direct contact with animals or consumption of Mycobacterium bovis infected animal products. In order to understand and quantify this risk and design intervention strategies, good epidemiological studies are needed. Such studies can include molecular typing of M. bovis isolates. The aim of this study was to apply these tools to provide novel information concerning the distribution of bovine tuberculosis in cattle in Mozambique and thereby provide relevant information to guide policy development and strategies to contain the disease in livestock, and reduce the risk associated with transmission to humans. A collection of 178 M. bovis isolates was obtained from cattle in Mozambique. Using spoligotyping and regions of difference analysis, we classified the isolates into clonal complexes, thus reporting the first characterisation of M. bovis strains in this region. Data from MIRU-VNTR typing was used to compare isolates from a number of African countries, revealing a deeply geographically structured diversity of M. bovis. Eastern Africa appears to show high diversity, suggesting deep evolution in that region. The diversity of M. bovis in Africa does not seem to be a function of recent importation of animals, but is probably maintained within each particular region by constant reinfection from reservoir animals. Understanding the transmission routes of M. bovis in Mozambique and elsewhere is essential in order to focus public health and veterinary resources to contain bovine tuberculosis.application/pdfporGenetic diversity and potential routes of transmission of Mycobacterium bovis in MozambiqueMachado, AdelinaRito, TeresaGhebremichael, SolomonMuhate, NuelmaMaxhuza, GabrielMacuamule, CustodiaMoiane, IvaniaMacucule, BaltazarMarranangumbe, Angelica SuzanaBaptista, JorgeManguele, JoaquimKoivula, TuijaStreicher, Elizabeth MariaWarren, Robin MarkKallenius, Gunillavan Helden, PaulCorreia-Neves, MHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONMachado, A., Rito, T., Ghebremichael, S., Muhate, N., et. al.(2018). Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique. PLoS neglected tropical diseases, 12(1), e0006147PMID29346413ISSNIsPartOf1935-2727EISSNIsPartOf1935-2735DOIIsPartOf10.1371/journal.pntd.00061472019-01-07T16:15:40Z2018-012018-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/57875http://purl.org/coar/access_right/c_abf2open accessAnimalsCattleGenotypeMolecular EpidemiologyMolecular TypingMozambiqueMycobacterium bovisTuberculosis, BovineZoonosesDisease Transmission, InfectiousGenetic Variationhttp://www.oecd.org/science/inno/38235147.pdfFields of Science and Technology (FOS)Ciências Médicas::Medicina Básica2579891 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/67985ee9-c456-47d1-ad27-e57b52c6deb8/download |
| spellingShingle | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique Machado, Adelina Animals Cattle Genotype Molecular Epidemiology Molecular Typing Mozambique Mycobacterium bovis Tuberculosis, Bovine Zoonoses Disease Transmission, Infectious Genetic Variation Ciências Médicas::Medicina Básica |
| status | SINGLETON |
| subject.fl_str_mv | Animals Cattle Genotype Molecular Epidemiology Molecular Typing Mozambique Mycobacterium bovis Tuberculosis, Bovine Zoonoses Disease Transmission, Infectious Genetic Variation |
| subject.other.fl_str_mv | Ciências Médicas::Medicina Básica |
| title | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique |
| title_full | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique |
| title_fullStr | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique |
| title_full_unstemmed | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique |
| title_short | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique |
| title_sort | Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique |
| topic | Animals Cattle Genotype Molecular Epidemiology Molecular Typing Mozambique Mycobacterium bovis Tuberculosis, Bovine Zoonoses Disease Transmission, Infectious Genetic Variation Ciências Médicas::Medicina Básica |
| topic_facet | Animals Cattle Genotype Molecular Epidemiology Molecular Typing Mozambique Mycobacterium bovis Tuberculosis, Bovine Zoonoses Disease Transmission, Infectious Genetic Variation Ciências Médicas::Medicina Básica |
| url | https://hdl.handle.net/1822/57875 |
| visible | 1 |