Detalhes bibliográficos
| Resumo: | The selectivity of photosensitizers for light activation is a key advantage in photodynamic therapy (PDT), allowing for precise targeting while sparing healthy cells. BODIPY derivatives have emerged as promising PDT candidates due to their tunable photophysical properties and versatile synthesis. Herein, we explore the photophysical characterization and the in vitro photodynamic activity of BODIPY analogues meso-substituted with an anthracene moiety and functionalized with iodine atoms or formyl group at 2,6-position. The formylated anthracene-BODIPY derivative exhibited the highest tumor suppression under irradiation, making it a potential candidate as PDT photosensitizer. |
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| Autores principais: | Gonçalves, Raquel Costa Raínha |
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| Outros Autores: | Pinto, Sónia Catarina Silva; Pina, João; Gomes-da-Silva, Lígia C.; Costa, Susana P. G.; Raposo, M. Manuela M. |
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| Assunto: | BODIPY derivative Cancer therapy Photosensitizers PDT Singlet oxygen quantum yield Synthesis Heterocycles Vilsmeier formylation In vitro assays Photodynamic therapy Ciências Naturais::Ciências Químicas Saúde de qualidade |
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| Ano: | 2023 |
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| País: | Portugal |
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| Tipo de documento: | comunicação em conferência |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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