Publicação
Mnn2 gene affects drug resistance in Candida glabratas biofilms
| Resumo: | Infections caused by Candida species have increased worldwide substantially over the latest decades, and are a significant cause of morbidity and mortality, mostly among critically ill patients. Candida glabrata is the second most common Candida responsible for these infections in the USA and the third in Europe, and is characterized by a high antifungal resistance. The goal of this study was to understand the role of mannans in C. glabrata biofilms and in biofilm cells resistance to antifungal drugs (fluconazole - Flu, amphotericin B - AmB, caspofungin - Csf and micafungin - Mcf) |
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| Autores principais: | Rodrigues, Célia Fortuna |
| Outros Autores: | Rodrigues, Maria Elisa Costa; Aimes, Lauren; Haines, Ken; Henriques, Mariana |
| Assunto: | Candida glabrata Antifungal Resistance MNN2 gene Drug Biofilms |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Infections caused by Candida species have increased worldwide substantially over the latest decades, and are a significant cause of morbidity and mortality, mostly among critically ill patients. Candida glabrata is the second most common Candida responsible for these infections in the USA and the third in Europe, and is characterized by a high antifungal resistance. The goal of this study was to understand the role of mannans in C. glabrata biofilms and in biofilm cells resistance to antifungal drugs (fluconazole - Flu, amphotericin B - AmB, caspofungin - Csf and micafungin - Mcf) |
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