Publicação
Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats
| Resumo: | In the present study, mono- and multi-material laser textured Ti6Al4V implants are manufactured and characterized in vivo to explore their applicability in orthopedic implants. Laser surface texturing is used for manufacturing grooved Ti6Al4V implants while a pressure-assisted sintering technique is employed to impregnate beta-tricalcium phosphate into grooves for an improved bioactivity. After implantation into Sprague Dawley rat's femur for 4 and 12 weeks, bone-implant fixation and osseointegration are assessed, by performing push-out tests and histological characterization. Histological characterization showed bone formation around all implants, characterized by immature bone at 4 weeks of implantation and a more mature bone after 12 weeks. The maximum push-out forces are higher for the textured and multi-material solution, when compared to non-textured implants right after 4 weeks of implantation (p < 0.05). After 12 weeks, multi-material implant displayed higher fracture energy when compared to non-textured implants (p < 0.05). Results revealed that laser surface texturing and bioactive multi-material solutions are highly effective to promote bone regeneration and enhance bone-implant fixation for further application in orthopedic implants. |
|---|---|
| Autores principais: | Costa, Ana Mafalda Meneses |
| Outros Autores: | Miranda, Alice Augusta Macedo; Bartolomeu, Flávio; Carvalho, Óscar Samuel Novais; Matos, Sergio; Silva, Filipe Samuel; Miranda, Maria Georgina Macedo |
| Assunto: | In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-beta TCP Ti6Al4V-β TCP |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867439351919542272 |
|---|---|
| author | Costa, Ana Mafalda Meneses |
| author2 | Miranda, Alice Augusta Macedo Bartolomeu, Flávio Carvalho, Óscar Samuel Novais Matos, Sergio Silva, Filipe Samuel Miranda, Maria Georgina Macedo |
| author2_role | author author author author author author |
| author_facet | Costa, Ana Mafalda Meneses Miranda, Alice Augusta Macedo Bartolomeu, Flávio Carvalho, Óscar Samuel Novais Matos, Sergio Silva, Filipe Samuel Miranda, Maria Georgina Macedo |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Costa, Ana Mafalda Meneses\"},{\"Person.name\":\"Miranda, Alice Augusta Macedo\"},{\"Person.name\":\"Bartolomeu, Flávio\"},{\"Person.name\":\"Carvalho, Óscar Samuel Novais\"},{\"Person.name\":\"Matos, Sergio\"},{\"Person.name\":\"Silva, Filipe Samuel\"},{\"Person.name\":\"Miranda, Maria Georgina Macedo\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Costa, Ana Mafalda Meneses Miranda, Alice Augusta Macedo Bartolomeu, Flávio Carvalho, Óscar Samuel Novais Matos, Sergio Silva, Filipe Samuel Miranda, Maria Georgina Macedo |
| datacite.date.Accepted.fl_str_mv | 2022-06-01T00:00:00Z |
| datacite.date.embargoed.fl_str_mv | 10000-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-beta TCP Ti6Al4V-β TCP |
| datacite.titles.title.fl_str_mv | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Costa, Ana Mafalda Meneses Miranda, Alice Augusta Macedo Bartolomeu, Flávio Carvalho, Óscar Samuel Novais Matos, Sergio Silva, Filipe Samuel Miranda, Maria Georgina Macedo |
| dc.date.Accepted.fl_str_mv | 2022-06-01T00:00:00Z |
| dc.date.embargoed.fl_str_mv | 10000-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/90078 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-beta TCP Ti6Al4V-β TCP |
| dc.title.fl_str_mv | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | In the present study, mono- and multi-material laser textured Ti6Al4V implants are manufactured and characterized in vivo to explore their applicability in orthopedic implants. Laser surface texturing is used for manufacturing grooved Ti6Al4V implants while a pressure-assisted sintering technique is employed to impregnate beta-tricalcium phosphate into grooves for an improved bioactivity. After implantation into Sprague Dawley rat's femur for 4 and 12 weeks, bone-implant fixation and osseointegration are assessed, by performing push-out tests and histological characterization. Histological characterization showed bone formation around all implants, characterized by immature bone at 4 weeks of implantation and a more mature bone after 12 weeks. The maximum push-out forces are higher for the textured and multi-material solution, when compared to non-textured implants right after 4 weeks of implantation (p < 0.05). After 12 weeks, multi-material implant displayed higher fracture energy when compared to non-textured implants (p < 0.05). Results revealed that laser surface texturing and bioactive multi-material solutions are highly effective to promote bone regeneration and enhance bone-implant fixation for further application in orthopedic implants. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/60b6ffc5-acd2-4cab-a883-efaa0f44fce5/download |
| id | rum_cbc3e63f251d267a4b43f9a6c19ec4b5 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/90078 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/90078 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Costa, Ana Mafalda Meneses Miranda, Alice Augusta Macedo Bartolomeu, Flávio Carvalho, Óscar Samuel Novais Matos, Sergio Silva, Filipe Samuel Miranda, Maria Georgina Macedo |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engWileyporIn the present study, mono- and multi-material laser textured Ti6Al4V implants are manufactured and characterized in vivo to explore their applicability in orthopedic implants. Laser surface texturing is used for manufacturing grooved Ti6Al4V implants while a pressure-assisted sintering technique is employed to impregnate beta-tricalcium phosphate into grooves for an improved bioactivity. After implantation into Sprague Dawley rat's femur for 4 and 12 weeks, bone-implant fixation and osseointegration are assessed, by performing push-out tests and histological characterization. Histological characterization showed bone formation around all implants, characterized by immature bone at 4 weeks of implantation and a more mature bone after 12 weeks. The maximum push-out forces are higher for the textured and multi-material solution, when compared to non-textured implants right after 4 weeks of implantation (p < 0.05). After 12 weeks, multi-material implant displayed higher fracture energy when compared to non-textured implants (p < 0.05). Results revealed that laser surface texturing and bioactive multi-material solutions are highly effective to promote bone regeneration and enhance bone-implant fixation for further application in orthopedic implants.application/pdfporOsseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in ratsCosta, Ana Mafalda MenesesMiranda, Alice Augusta MacedoBartolomeu, FlávioCarvalho, Óscar Samuel NovaisMatos, SergioSilva, Filipe SamuelMiranda, Maria Georgina MacedoHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONM. M. Costa, A. Miranda, F. Bartolomeu, Ó. Carvalho, S. Matos, F. S. Silva, G. Miranda, Osseointegration Assessment of Multi-Material Ti6Al4V-β TCP Implants: An Experimental Study in Rats. Adv. Mater. Technol. 2022, 7, 2101117. https://doi.org/10.1002/admt.202101117ARTICLENUMBER2101117ISSNIsPartOf2365-709XDOIIsPartOf10.1002/admt.2021011172022-062024-03-21T12:05:47Z2022-06-01T00:00:00Z10000-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/90078http://purl.org/coar/access_right/c_16ecrestricted accessIn vivoLaser surface texturingMulti-materialOsseointegrationTi6Al4V-beta TCPTi6Al4V-β TCP1172218 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_f1cfapplication/pdffulltexthttps://repositorium.uminho.pt/bitstreams/60b6ffc5-acd2-4cab-a883-efaa0f44fce5/download |
| spellingShingle | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats Costa, Ana Mafalda Meneses In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-beta TCP Ti6Al4V-β TCP |
| status | SINGLETON |
| subject.fl_str_mv | In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-beta TCP Ti6Al4V-β TCP |
| title | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
| title_full | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
| title_fullStr | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
| title_full_unstemmed | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
| title_short | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
| title_sort | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
| topic | In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-beta TCP Ti6Al4V-β TCP |
| topic_facet | In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-beta TCP Ti6Al4V-β TCP |
| url | https://hdl.handle.net/1822/90078 |
| visible | 1 |