Publicação
Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
| Resumo: | The literature on gait analysis in Vascular Parkinsonism (VaP), addressing issues such as variability, foot clearance patterns, and the effect of levodopa, is scarce. This study investigates whether spatiotemporal, foot clearance and stride-to-stride variability analysis can discriminate VaP, and responsiveness to levodopa. Fifteen healthy subjects, 15 Idiopathic Parkinson's Disease (IPD) patients and 15 VaP patients, were assessed in two phases: before (Off-state), and one hour after (On-state) the acute administration of a suprathreshold (1.5 times the usual) levodopa dose. Participants were asked to walk a 30-meter continuous course at a self-selected walking speed while wearing foot-worn inertial sensors. For each gait variable, mean, coefficient of variation (CV), and standard deviations SD1 and SD2 obtained by Poincaré analysis were calculated. General linear models (GLMs) were used to identify group differences. Patients were subject to neuropsychological evaluation (MoCA test) and Brain MRI. VaP patients presented lower mean stride velocity, stride length, lift-off and strike angle, and height of maximum toe (later swing) (p < .05), and higher %gait cycle in double support, with only the latter unresponsive to levodopa. VaP patients also presented higher CV, significantly reduced after levodopa. Yet, all VaP versus IPD differences lost significance when accounting for mean stride length as a covariate. In conclusion, VaP patients presented a unique gait with reduced degrees of foot clearance, probably correlated to vascular lesioning in dopaminergic/non-dopaminergic cortical and subcortical non-dopaminergic networks, still amenable to benefit from levodopa. The dependency of gait and foot clearance and variability deficits from stride length deserves future clarification. |
|---|---|
| Autores principais: | Ferreira, Flora |
| Outros Autores: | Gago, Miguel F.; Bicho, Estela; Carvalho, Catarina; Mollaei, Nafiseh; Rodrigues, Lurdes; Sousa, Nuno; Rodrigues, Pedro Pereira; Ferreira, Carlos; Gama, João |
| Assunto: | Vascular Parkinsonism Idiopathic Parkinson's disease Toe and heel clearance Short and long-term gait variability Levodopa Ciências Médicas::Medicina Básica |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1867439203893116928 |
|---|---|
| author | Ferreira, Flora |
| author2 | Gago, Miguel F. Bicho, Estela Carvalho, Catarina Mollaei, Nafiseh Rodrigues, Lurdes Sousa, Nuno Rodrigues, Pedro Pereira Ferreira, Carlos Gama, João |
| author2_role | author author author author author author author author author |
| author_facet | Ferreira, Flora Gago, Miguel F. Bicho, Estela Carvalho, Catarina Mollaei, Nafiseh Rodrigues, Lurdes Sousa, Nuno Rodrigues, Pedro Pereira Ferreira, Carlos Gama, João |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ferreira, Flora\"},{\"Person.name\":\"Gago, Miguel F.\"},{\"Person.name\":\"Bicho, Estela\"},{\"Person.name\":\"Carvalho, Catarina\"},{\"Person.name\":\"Mollaei, Nafiseh\"},{\"Person.name\":\"Rodrigues, Lurdes\"},{\"Person.name\":\"Sousa, Nuno\"},{\"Person.name\":\"Rodrigues, Pedro Pereira\"},{\"Person.name\":\"Ferreira, Carlos\"},{\"Person.name\":\"Gama, João\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Ferreira, Flora Gago, Miguel F. Bicho, Estela Carvalho, Catarina Mollaei, Nafiseh Rodrigues, Lurdes Sousa, Nuno Rodrigues, Pedro Pereira Ferreira, Carlos Gama, João |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-07-19T06:00:19Z |
| datacite.date.embargoed.fl_str_mv | 2020-07-19T06:00:19Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Vascular Parkinsonism Idiopathic Parkinson's disease Toe and heel clearance Short and long-term gait variability Levodopa Ciências Médicas::Medicina Básica |
| datacite.titles.title.fl_str_mv | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Ferreira, Flora Gago, Miguel F. Bicho, Estela Carvalho, Catarina Mollaei, Nafiseh Rodrigues, Lurdes Sousa, Nuno Rodrigues, Pedro Pereira Ferreira, Carlos Gama, João |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-07-19T06:00:19Z |
| dc.date.embargoed.fl_str_mv | 2020-07-19T06:00:19Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/62328 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Vascular Parkinsonism Idiopathic Parkinson's disease Toe and heel clearance Short and long-term gait variability Levodopa Ciências Médicas::Medicina Básica |
| dc.title.fl_str_mv | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The literature on gait analysis in Vascular Parkinsonism (VaP), addressing issues such as variability, foot clearance patterns, and the effect of levodopa, is scarce. This study investigates whether spatiotemporal, foot clearance and stride-to-stride variability analysis can discriminate VaP, and responsiveness to levodopa. Fifteen healthy subjects, 15 Idiopathic Parkinson's Disease (IPD) patients and 15 VaP patients, were assessed in two phases: before (Off-state), and one hour after (On-state) the acute administration of a suprathreshold (1.5 times the usual) levodopa dose. Participants were asked to walk a 30-meter continuous course at a self-selected walking speed while wearing foot-worn inertial sensors. For each gait variable, mean, coefficient of variation (CV), and standard deviations SD1 and SD2 obtained by Poincaré analysis were calculated. General linear models (GLMs) were used to identify group differences. Patients were subject to neuropsychological evaluation (MoCA test) and Brain MRI. VaP patients presented lower mean stride velocity, stride length, lift-off and strike angle, and height of maximum toe (later swing) (p < .05), and higher %gait cycle in double support, with only the latter unresponsive to levodopa. VaP patients also presented higher CV, significantly reduced after levodopa. Yet, all VaP versus IPD differences lost significance when accounting for mean stride length as a covariate. In conclusion, VaP patients presented a unique gait with reduced degrees of foot clearance, probably correlated to vascular lesioning in dopaminergic/non-dopaminergic cortical and subcortical non-dopaminergic networks, still amenable to benefit from levodopa. The dependency of gait and foot clearance and variability deficits from stride length deserves future clarification. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorium.uminho.pt/bitstreams/a9026385-8321-4ca5-b701-95d4f3dc8f09/download |
| id | rum_ed9c25a3a38bbef3b779db33dfeda0ff |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/62328 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/62328 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Ferreira, Flora Gago, Miguel F. Bicho, Estela Carvalho, Catarina Mollaei, Nafiseh Rodrigues, Lurdes Sousa, Nuno Rodrigues, Pedro Pereira Ferreira, Carlos Gama, João |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engElsevierporThe literature on gait analysis in Vascular Parkinsonism (VaP), addressing issues such as variability, foot clearance patterns, and the effect of levodopa, is scarce. This study investigates whether spatiotemporal, foot clearance and stride-to-stride variability analysis can discriminate VaP, and responsiveness to levodopa. Fifteen healthy subjects, 15 Idiopathic Parkinson's Disease (IPD) patients and 15 VaP patients, were assessed in two phases: before (Off-state), and one hour after (On-state) the acute administration of a suprathreshold (1.5 times the usual) levodopa dose. Participants were asked to walk a 30-meter continuous course at a self-selected walking speed while wearing foot-worn inertial sensors. For each gait variable, mean, coefficient of variation (CV), and standard deviations SD1 and SD2 obtained by Poincaré analysis were calculated. General linear models (GLMs) were used to identify group differences. Patients were subject to neuropsychological evaluation (MoCA test) and Brain MRI. VaP patients presented lower mean stride velocity, stride length, lift-off and strike angle, and height of maximum toe (later swing) (p < .05), and higher %gait cycle in double support, with only the latter unresponsive to levodopa. VaP patients also presented higher CV, significantly reduced after levodopa. Yet, all VaP versus IPD differences lost significance when accounting for mean stride length as a covariate. In conclusion, VaP patients presented a unique gait with reduced degrees of foot clearance, probably correlated to vascular lesioning in dopaminergic/non-dopaminergic cortical and subcortical non-dopaminergic networks, still amenable to benefit from levodopa. The dependency of gait and foot clearance and variability deficits from stride length deserves future clarification.application/pdfporGait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular ParkinsonismFerreira, FloraGago, Miguel F.Bicho, EstelaCarvalho, CatarinaMollaei, NafisehRodrigues, LurdesSousa, NunoRodrigues, Pedro PereiraFerreira, CarlosGama, JoãoHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONFerreira, F., Gago, M. F., et. al. (2019). Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson’s Disease and Vascular Parkinsonism. Journal of biomechanics.PMID31182234ISSNIsPartOf0021-9290EISSNIsPartOf1873-2380DOIIsPartOf10.1016/j.jbiomech.2019.05.0392020-07-19T06:00:19Z20192019-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/62328http://purl.org/coar/access_right/c_abf2open accessVascular ParkinsonismIdiopathic Parkinson's diseaseToe and heel clearanceShort and long-term gait variabilityLevodopahttp://www.oecd.org/science/inno/38235147.pdfFields of Science and Technology (FOS)Ciências Médicas::Medicina Básica1150642 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorium.uminho.pt/bitstreams/a9026385-8321-4ca5-b701-95d4f3dc8f09/download |
| spellingShingle | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism Ferreira, Flora Vascular Parkinsonism Idiopathic Parkinson's disease Toe and heel clearance Short and long-term gait variability Levodopa Ciências Médicas::Medicina Básica |
| status | SINGLETON |
| subject.fl_str_mv | Vascular Parkinsonism Idiopathic Parkinson's disease Toe and heel clearance Short and long-term gait variability Levodopa |
| subject.other.fl_str_mv | Ciências Médicas::Medicina Básica |
| title | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism |
| title_full | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism |
| title_fullStr | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism |
| title_full_unstemmed | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism |
| title_short | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism |
| title_sort | Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism |
| topic | Vascular Parkinsonism Idiopathic Parkinson's disease Toe and heel clearance Short and long-term gait variability Levodopa Ciências Médicas::Medicina Básica |
| topic_facet | Vascular Parkinsonism Idiopathic Parkinson's disease Toe and heel clearance Short and long-term gait variability Levodopa Ciências Médicas::Medicina Básica |
| url | https://hdl.handle.net/1822/62328 |
| visible | 1 |