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Measurement of the mucoadhesive strength of silica microparticles with different surface characteristics

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Resumo:Mesoporous Silicon particles have been intensively investigated for their utility in drug delivery systems and for allowing the improvement in terms of pharmacokinetic properties of nouvelle molecules or older ones with poor absorption in oral route administrations. In this work we optimized and perfected a method based in the application of a perpendicular force to rat small intestine segments mounted in cells, after being incubated in Easy-Mount diffusion chambers, using a modified precision balance. Subsequently we evaluated the mucoadhesion strength properties of TCPSi, TC-non-PSi, THCPSi, THC-non-PSi, NH2TCPSi and NH2TC-non-PSi microparticles, using CMC Na polymer as a positive control and polyacrylate’s smooth surface as negative control. All of the samples proved to adhere to the intestine’s mucosa, by this order of values: 56,50mN/cm2 Polymer CMC Na > 45,4 mN/cm2 TCPSi = 45,5 mN/cm2 THC-non-PSi > 43,1 mN/cm2 NH2TCPSi > 38,186 mN/cm2 NH2-non-TCPSi > 36,3 mN/cm2 THCPSi > 26,9 mN/cm2 TC-non-PSi > 21,81mN/cm2 Polyacrylate. Measuring the mucoadhesion after multiple attachments and detachments, all of the nanostructured Silicon microparticles presented increasing mucoadhesion strength, while the polymer CMC Na based mucoadhesion decreases with the number of attachments and detachments. Our work sets a solid foundation for future in vitro and in vivo assays, planned to better understand the mucoadhesion mechanism and its effect on the pharmaceutical formulation’s retention in the gastrointestinal tract.
Autores principais:Ferreira, César Fernando da Cunha
Assunto:Mestrado Integrado - 2014
Ano:2014
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso restrito
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa

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