Publicação
Coma in adult cerebral venous thrombosis: the BEAST study
| Resumo: | Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model. Results: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5-60) versus 40 (33-47) years in the coma (p = 0.04) and 44.5 (34-58) versus 37 (29-48) years in the non-coma sample (p < 0.001), respectively. Furthermore, an age- and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0-3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52-0.68, p = 0.01). Conclusions: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women. |
|---|---|
| Autores principais: | Ranjan, Redoy |
| Outros Autores: | Ken‐Dror, Gie; Martinelli, Ida; Grandone, Elvira; Hiltunen, Sini; Lindgren, Erik; Margaglione, Maurizio; Duchez, Veronique Le Cam; Triquenot Bagan, Aude; Zedde, Marialuisa; Giannini, Nicola; Ruigrok, Ynte M.; Worrall, Bradford B.; Majersik, Jennifer J.; Putaala, Jukka; Haapaniemi, Elena; Zuurbier, Susanna M.; Brouwer, Matthijs C.; Passamonti, Serena M.; Abbattista, Maria; Bucciarelli, Paolo; Lemmens, Robin; Pappalardo, Emanuela; Costa, Paolo; Colombi, Marina; de Sousa, Diana Aguiar; Rodrigues, Sofia; Canhão, Patrícia; Tkach, Aleksander; Santacroce, Rosa; Favuzzi, Giovanni; Arauz, Antonio; Colaizzo, Donatella; Spengos, Kostas; Hodge, Amanda; Ditta, Reina; Pezzini, Alessandro; Coutinho, Jonathan M.; Thijs, Vincent; Jood, Katarina; Tatlisumak, Turgut; Ferro, José; Sharma, Pankaj |
| Assunto: | CVT Cerebral venous thrombosis Characteristics Coma Predictors Women |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866810588103966720 |
|---|---|
| author | Ranjan, Redoy |
| author2 | Ken‐Dror, Gie Martinelli, Ida Grandone, Elvira Hiltunen, Sini Lindgren, Erik Margaglione, Maurizio Duchez, Veronique Le Cam Triquenot Bagan, Aude Zedde, Marialuisa Giannini, Nicola Ruigrok, Ynte M. Worrall, Bradford B. Majersik, Jennifer J. Putaala, Jukka Haapaniemi, Elena Zuurbier, Susanna M. Brouwer, Matthijs C. Passamonti, Serena M. Abbattista, Maria Bucciarelli, Paolo Lemmens, Robin Pappalardo, Emanuela Costa, Paolo Colombi, Marina de Sousa, Diana Aguiar Rodrigues, Sofia Canhão, Patrícia Tkach, Aleksander Santacroce, Rosa Favuzzi, Giovanni Arauz, Antonio Colaizzo, Donatella Spengos, Kostas Hodge, Amanda Ditta, Reina Pezzini, Alessandro Coutinho, Jonathan M. Thijs, Vincent Jood, Katarina Tatlisumak, Turgut Ferro, José Sharma, Pankaj |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Ranjan, Redoy Ken‐Dror, Gie Martinelli, Ida Grandone, Elvira Hiltunen, Sini Lindgren, Erik Margaglione, Maurizio Duchez, Veronique Le Cam Triquenot Bagan, Aude Zedde, Marialuisa Giannini, Nicola Ruigrok, Ynte M. Worrall, Bradford B. Majersik, Jennifer J. Putaala, Jukka Haapaniemi, Elena Zuurbier, Susanna M. Brouwer, Matthijs C. Passamonti, Serena M. Abbattista, Maria Bucciarelli, Paolo Lemmens, Robin Pappalardo, Emanuela Costa, Paolo Colombi, Marina de Sousa, Diana Aguiar Rodrigues, Sofia Canhão, Patrícia Tkach, Aleksander Santacroce, Rosa Favuzzi, Giovanni Arauz, Antonio Colaizzo, Donatella Spengos, Kostas Hodge, Amanda Ditta, Reina Pezzini, Alessandro Coutinho, Jonathan M. Thijs, Vincent Jood, Katarina Tatlisumak, Turgut Ferro, José Sharma, Pankaj |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ranjan, Redoy\"},{\"Person.name\":\"Ken‐Dror, Gie\"},{\"Person.name\":\"Martinelli, Ida\"},{\"Person.name\":\"Grandone, Elvira\"},{\"Person.name\":\"Hiltunen, Sini\"},{\"Person.name\":\"Lindgren, Erik\"},{\"Person.name\":\"Margaglione, Maurizio\"},{\"Person.name\":\"Duchez, Veronique Le Cam\"},{\"Person.name\":\"Triquenot Bagan, Aude\"},{\"Person.name\":\"Zedde, Marialuisa\"},{\"Person.name\":\"Giannini, Nicola\"},{\"Person.name\":\"Ruigrok, Ynte M.\"},{\"Person.name\":\"Worrall, Bradford B.\"},{\"Person.name\":\"Majersik, Jennifer J.\"},{\"Person.name\":\"Putaala, Jukka\"},{\"Person.name\":\"Haapaniemi, Elena\"},{\"Person.name\":\"Zuurbier, Susanna M.\"},{\"Person.name\":\"Brouwer, Matthijs C.\"},{\"Person.name\":\"Passamonti, Serena M.\"},{\"Person.name\":\"Abbattista, Maria\"},{\"Person.name\":\"Bucciarelli, Paolo\"},{\"Person.name\":\"Lemmens, Robin\"},{\"Person.name\":\"Pappalardo, Emanuela\"},{\"Person.name\":\"Costa, Paolo\"},{\"Person.name\":\"Colombi, Marina\"},{\"Person.name\":\"de Sousa, Diana Aguiar\",\"Person.identifier.orcid\":\"0000-0002-6702-7924\"},{\"Person.name\":\"Rodrigues, Sofia\"},{\"Person.name\":\"Canhão, Patrícia\",\"Person.identifier.orcid\":\"0000-0003-3816-0416\"},{\"Person.name\":\"Tkach, Aleksander\"},{\"Person.name\":\"Santacroce, Rosa\"},{\"Person.name\":\"Favuzzi, Giovanni\"},{\"Person.name\":\"Arauz, Antonio\"},{\"Person.name\":\"Colaizzo, Donatella\"},{\"Person.name\":\"Spengos, Kostas\"},{\"Person.name\":\"Hodge, Amanda\"},{\"Person.name\":\"Ditta, Reina\"},{\"Person.name\":\"Pezzini, Alessandro\"},{\"Person.name\":\"Coutinho, Jonathan M.\"},{\"Person.name\":\"Thijs, Vincent\"},{\"Person.name\":\"Jood, Katarina\"},{\"Person.name\":\"Tatlisumak, Turgut\"},{\"Person.name\":\"Ferro, José\",\"Person.identifier.orcid\":\"0000-0002-2343-9097\"},{\"Person.name\":\"Sharma, Pankaj\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Ranjan, Redoy Ken‐Dror, Gie Martinelli, Ida Grandone, Elvira Hiltunen, Sini Lindgren, Erik Margaglione, Maurizio Duchez, Veronique Le Cam Triquenot Bagan, Aude Zedde, Marialuisa Giannini, Nicola Ruigrok, Ynte M. Worrall, Bradford B. Majersik, Jennifer J. Putaala, Jukka Haapaniemi, Elena Zuurbier, Susanna M. Brouwer, Matthijs C. Passamonti, Serena M. Abbattista, Maria Bucciarelli, Paolo Lemmens, Robin Pappalardo, Emanuela Costa, Paolo Colombi, Marina de Sousa, Diana Aguiar Rodrigues, Sofia Canhão, Patrícia Tkach, Aleksander Santacroce, Rosa Favuzzi, Giovanni Arauz, Antonio Colaizzo, Donatella Spengos, Kostas Hodge, Amanda Ditta, Reina Pezzini, Alessandro Coutinho, Jonathan M. Thijs, Vincent Jood, Katarina Tatlisumak, Turgut Ferro, José Sharma, Pankaj |
| datacite.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-11-19T14:53:36Z |
| datacite.date.embargoed.fl_str_mv | 2024-11-19T14:53:36Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | CVT Cerebral venous thrombosis Characteristics Coma Predictors Women |
| datacite.titles.title.fl_str_mv | Coma in adult cerebral venous thrombosis: the BEAST study |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Ranjan, Redoy Ken‐Dror, Gie Martinelli, Ida Grandone, Elvira Hiltunen, Sini Lindgren, Erik Margaglione, Maurizio Duchez, Veronique Le Cam Triquenot Bagan, Aude Zedde, Marialuisa Giannini, Nicola Ruigrok, Ynte M. Worrall, Bradford B. Majersik, Jennifer J. Putaala, Jukka Haapaniemi, Elena Zuurbier, Susanna M. Brouwer, Matthijs C. Passamonti, Serena M. Abbattista, Maria Bucciarelli, Paolo Lemmens, Robin Pappalardo, Emanuela Costa, Paolo Colombi, Marina de Sousa, Diana Aguiar Rodrigues, Sofia Canhão, Patrícia Tkach, Aleksander Santacroce, Rosa Favuzzi, Giovanni Arauz, Antonio Colaizzo, Donatella Spengos, Kostas Hodge, Amanda Ditta, Reina Pezzini, Alessandro Coutinho, Jonathan M. Thijs, Vincent Jood, Katarina Tatlisumak, Turgut Ferro, José Sharma, Pankaj |
| dc.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-11-19T14:53:36Z |
| dc.date.embargoed.fl_str_mv | 2024-11-19T14:53:36Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.5/95438 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | CVT Cerebral venous thrombosis Characteristics Coma Predictors Women |
| dc.title.fl_str_mv | Coma in adult cerebral venous thrombosis: the BEAST study |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model. Results: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5-60) versus 40 (33-47) years in the coma (p = 0.04) and 44.5 (34-58) versus 37 (29-48) years in the non-coma sample (p < 0.001), respectively. Furthermore, an age- and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0-3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52-0.68, p = 0.01). Conclusions: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women. |
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| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/c31a52fb-54bc-4d0e-b4e4-e15b07dca9bb/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10400.5/95438 |
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| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
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| person_str_mv | Ranjan, Redoy Ken‐Dror, Gie Martinelli, Ida Grandone, Elvira Hiltunen, Sini Lindgren, Erik Margaglione, Maurizio Duchez, Veronique Le Cam Triquenot Bagan, Aude Zedde, Marialuisa Giannini, Nicola Ruigrok, Ynte M. Worrall, Bradford B. Majersik, Jennifer J. Putaala, Jukka Haapaniemi, Elena Zuurbier, Susanna M. Brouwer, Matthijs C. Passamonti, Serena M. Abbattista, Maria Bucciarelli, Paolo Lemmens, Robin Pappalardo, Emanuela Costa, Paolo Colombi, Marina de Sousa, Diana Aguiar de Sousa, Diana Aguiar https://www.ciencia-id.pt/571C-121A-5CCB 571C-121A-5CCB http://orcid.org/0000-0002-6702-7924 0000-0002-6702-7924 Rodrigues, Sofia Canhão, Patrícia Canhão, Patrícia https://www.ciencia-id.pt/8F12-6A40-BE2E 8F12-6A40-BE2E http://orcid.org/0000-0003-3816-0416 0000-0003-3816-0416 Tkach, Aleksander Santacroce, Rosa Favuzzi, Giovanni Arauz, Antonio Colaizzo, Donatella Spengos, Kostas Hodge, Amanda Ditta, Reina Pezzini, Alessandro Coutinho, Jonathan M. Thijs, Vincent Jood, Katarina Tatlisumak, Turgut Ferro, José Ferro, José https://www.ciencia-id.pt/6F16-7E25-7AAF 6F16-7E25-7AAF http://orcid.org/0000-0002-2343-9097 0000-0002-2343-9097 Sharma, Pankaj |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | Repositório da Universidade de Lisboa |
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| spelling | engWileypt_PTBackground and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model. Results: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5-60) versus 40 (33-47) years in the coma (p = 0.04) and 44.5 (34-58) versus 37 (29-48) years in the non-coma sample (p < 0.001), respectively. Furthermore, an age- and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0-3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52-0.68, p = 0.01). Conclusions: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women.application/pdfpt_PTComa in adult cerebral venous thrombosis: the BEAST studyRanjan, RedoyKen‐Dror, GieMartinelli, IdaGrandone, ElviraHiltunen, SiniLindgren, ErikMargaglione, MaurizioDuchez, Veronique Le CamTriquenot Bagan, AudeZedde, MarialuisaGiannini, NicolaRuigrok, Ynte M.Worrall, Bradford B.Majersik, Jennifer J.Putaala, JukkaHaapaniemi, ElenaZuurbier, Susanna M.Brouwer, Matthijs C.Passamonti, Serena M.Abbattista, MariaBucciarelli, PaoloLemmens, RobinPappalardo, EmanuelaCosta, PaoloColombi, MarinaPersonalde Sousa, Diana AguiarDSpacehttp://dspace.org/items/1d984575-dd95-4ca1-9092-bf6f9914ba63DSpacehttp://dspace.org/items/1d984575-dd95-4ca1-9092-bf6f9914ba63Aguiar de SousaDianaCiência IDhttps://www.ciencia-id.pt571C-121A-5CCBORCIDhttp://orcid.org0000-0002-6702-7924Researcher IDhttps://www.researcherid.comJ-4105-2013Scopus Author IDhttps://www.scopus.com55781226000Rodrigues, SofiaPersonalCanhão, PatríciaDSpacehttp://dspace.org/items/e9d5a53f-d0d3-4cc4-9807-879ef76be505DSpacehttp://dspace.org/items/e9d5a53f-d0d3-4cc4-9807-879ef76be505CanhãoPatríciaCiência IDhttps://www.ciencia-id.pt8F12-6A40-BE2EORCIDhttp://orcid.org0000-0003-3816-0416Scopus Author IDhttps://www.scopus.com6603685711Tkach, AleksanderSantacroce, RosaFavuzzi, GiovanniArauz, AntonioColaizzo, DonatellaSpengos, KostasHodge, AmandaDitta, ReinaPezzini, AlessandroCoutinho, Jonathan M.Thijs, VincentJood, KatarinaTatlisumak, TurgutPersonalFerro, JoséDSpacehttp://dspace.org/items/9a568ce6-d218-44fc-982c-0ffe7bffc197DSpacehttp://dspace.org/items/9a568ce6-d218-44fc-982c-0ffe7bffc197Morão Cabral FerroJosé ManuelCiência IDhttps://www.ciencia-id.pt6F16-7E25-7AAFORCIDhttp://orcid.org0000-0002-2343-9097Sharma, PankajHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf1351-5101DOIIsPartOf10.1111/ene.163112024-11-19T14:53:36Z20242024-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.5/95438http://purl.org/coar/access_right/c_abf2open accessCVTCerebral venous thrombosisCharacteristicsComaPredictorsWomen319790 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2024http://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/c31a52fb-54bc-4d0e-b4e4-e15b07dca9bb/downloadEuropean Journal of Neurology318 |
| spellingShingle | Coma in adult cerebral venous thrombosis: the BEAST study Ranjan, Redoy CVT Cerebral venous thrombosis Characteristics Coma Predictors Women |
| status | SINGLETON |
| subject.fl_str_mv | CVT Cerebral venous thrombosis Characteristics Coma Predictors Women |
| title | Coma in adult cerebral venous thrombosis: the BEAST study |
| title_full | Coma in adult cerebral venous thrombosis: the BEAST study |
| title_fullStr | Coma in adult cerebral venous thrombosis: the BEAST study |
| title_full_unstemmed | Coma in adult cerebral venous thrombosis: the BEAST study |
| title_short | Coma in adult cerebral venous thrombosis: the BEAST study |
| title_sort | Coma in adult cerebral venous thrombosis: the BEAST study |
| topic | CVT Cerebral venous thrombosis Characteristics Coma Predictors Women |
| topic_facet | CVT Cerebral venous thrombosis Characteristics Coma Predictors Women |
| url | http://hdl.handle.net/10400.5/95438 |
| visible | 1 |