Publicação

Diabetes mellitus e osteoporose

Ver documento

Detalhes bibliográficos
Resumo:The association between diabetes mellitus (DM) and osteoporosis (OT) is a controversial issue that has been investigated due to its high prevalence and incidence. Studies suggest that patients with DM1 and DM2 have an increased risk of fractures and that bone formation and bone microarchitecture are altered in both. The risk of fracture seems to be related to such factors as low skeletal bone density in DM1 and poor bone quality in DM2, but there are also extra-skeletal factors that increase the risk of falling. The metabolic mechanisms that may affect bone metabolism in DM are hypothetical and several studies have been done in this area that indicate the direct effects of insulin deficiency or insulin resistance and hyperglycemia in bone and bone marrow, advanced glycation end products (AGES) of matrix proteins bone, abnormal adipokine production and skeletal neuromuscular disorders as primarily responsible for the increased risk of fracture in individuals with DM. In addition to the literature review, a study was conducted in patients with T2DM followed regularly in Hospital Santa Maria. The factors known to mineral metabolism and bone metabolic disease, appears to be irrelevant. Thus, according to the data analyzed, it appears that in DM, the universal factors of mineral metabolism are no longer relevant because there would be something else more important, related to the disease.
Autores principais:Sampaio, Nádia Andreia da Conceição
Assunto:Diabetes mellitus Osteoporose
Ano:2014
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso restrito
Instituição associada:Universidade de Lisboa
Idioma:português
Origem:Repositório da Universidade de Lisboa

Registos relacionados

Registos relacionados