Publicação
Primaquine–pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity
| Resumo: | A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver stage infection. |
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| Autores principais: | Kaur, Hardeep |
| Outros Autores: | Machado, Marta; de Kock, Carmen; Smith, Peter; Chibale, Kelly; Prudêncio, Miguel; Singh, Kamaljit |
| Assunto: | Antiplasmodial agents Blood stage activity Hybrid drugs Liver stage activity Primaquine Pyrimidine |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver stage infection. |
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