Publicação
The effects of capsaicin in the treatment on non-allergic rhinitis : a systematic review
| Resumo: | The management of patients with perennial nonallergic or idiopathic rhinitis is difficult. Diagnosis and treatment are hampered by several factors. First, the diagnosis is made by exclusion of other nasal diseases, essentially allergy tests such as RAST, skin prick tests. As a consequence, idiopathic rhinitis is not defined according to clear criteria. A commonly accepted phenotype of idiopathic rhinitis is not yet fully elucidated. In contrast with allergic rhinitis, inflammation does not appear to play a major role in idiopathic rhinitis. Recent studies indicate a neural dysregulation of the nasal mucosa. Additionally, the available therapeutic arsenal comprising both pharmacotherapy and surgery is at best partially efficacious in these patients. The efficacy of repeated capsaicin application has been established in several randomized controlled trials. This treatment modality nay be the first step to more specific and better treatment options for patients with idiopathic rhinitis that is unresponsive to standard treatment with steroids. |
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| Autores principais: | Caires, João Afonso Gonzalez de Almeida |
| Assunto: | Capsaicin Non allergic Rhinitis Nasal Obstruction |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | The management of patients with perennial nonallergic or idiopathic rhinitis is difficult. Diagnosis and treatment are hampered by several factors. First, the diagnosis is made by exclusion of other nasal diseases, essentially allergy tests such as RAST, skin prick tests. As a consequence, idiopathic rhinitis is not defined according to clear criteria. A commonly accepted phenotype of idiopathic rhinitis is not yet fully elucidated. In contrast with allergic rhinitis, inflammation does not appear to play a major role in idiopathic rhinitis. Recent studies indicate a neural dysregulation of the nasal mucosa. Additionally, the available therapeutic arsenal comprising both pharmacotherapy and surgery is at best partially efficacious in these patients. The efficacy of repeated capsaicin application has been established in several randomized controlled trials. This treatment modality nay be the first step to more specific and better treatment options for patients with idiopathic rhinitis that is unresponsive to standard treatment with steroids. |
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