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Clinical practice guidelines for management of parkinson’s disease : a systematic critical appraisal

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Resumo:Parkinson's disease (PD) is a neurodegenerative disease with increasing incidence and prevalence. The natural course of disease leads to a multiple symptoms requiring multiple pharmacological and non-pharmacological therapeutic options. Given this multiplicity, Clinical Practice Guidelines (CPGs) were created to assist health professionals making better choices supported in the best scientific evidence. As number of CPGs increases, concern about the quality of their methodological quality has raised too. Thus, it was created the Appraisal of Guidelines for Research and Evaluation (AGREE) instrument to assess the methodological quality of CPGs available. After a systematic literature search, this study will assess 11 CPGs corresponding to 5 different entities publications. To appraise the CPGs, AGREE II instrument will be applied by 4 independent reviewers. Then, the content of the recommendations will be compared as well as their strenght of recommendation. CPGs have, in general, recommendations based in high level of scientific evidence, especially with regard to the therapeutic options in the early disease and the management of motor complications. We concluded that is necessary further ivestigation regarding to management of neuro-psychiatric complications and autonomic nervous system disorders.
Autores principais:Duarte, Ivo Miguel Santos
Assunto:Doença de Parkinson Normas de Orientação Clínica (NOCs) Appraisal of Guidelines for Research and Evaluation (AGREE)
Ano:2014
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso restrito
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa

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