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Temporal patterns of microglial activation when bilirubin enters into the brain

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Detalhes bibliográficos
Resumo:Microglia turns into an activated state when facing injury and disease entailing two main functions: phagocytosis of cellular debris and propagation of immune response. Once unconjugated bilirubin (UCB) increases proinflammatory cytokine secretion by both astrocytes [1] and microglia [2], we aimed to assess the sequence of events involved in microglia immunophenotype by UCB.
Autores principais:Silva, SL
Outros Autores:Osório, CC; Vaz, AR; Barateiro, A; Falcão, AS; Brito, MA; Fernandes, A; Silva, RFM; Brites, D
Ano:2009
País:Portugal
Tipo de documento:documento de conferência
Tipo de acesso:acesso restrito
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa
Descrição
Resumo:Microglia turns into an activated state when facing injury and disease entailing two main functions: phagocytosis of cellular debris and propagation of immune response. Once unconjugated bilirubin (UCB) increases proinflammatory cytokine secretion by both astrocytes [1] and microglia [2], we aimed to assess the sequence of events involved in microglia immunophenotype by UCB.