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Cognitive deficits in middle-aged and older patients with bipolar disorder : comparison with mild cognitive impairment subjects

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Resumo:Background: The present literature has reported cognitive deficits in older bipolar disorder (BD) patients, namely in executive functions and verbal memory. Nevertheless, few studies have evaluated elderly BD patients using standardized cognitive assessments and more (to our knowledge) analysed elderly BD patients with recent cognitive complaints. Aim: Compare the cognitive deficits of middle-aged and older BD patients presenting cognitive complaints with the profile of impairment seen at the beginning of a neurodegenerative process, as in Mild Cognitive Impairment (MCI) patients. Method: A systematic search for all cases of BD patients with recent cognitive complaints submitted to a neuropsychological evaluation, from 1999 to 2007, at participant institutions, was performed, and cases were matched (1:2) by gender and age to a sample of MCI patients. Results: A sample of 135 patients: 45 patients with the diagnosis of BD, clinically stable, mean stage of 63.8 (8.8) years, and 90 patients with the diagnosos of MCI, mean age of 64.2 (8.4) years, was studied. BD patients showed more deficits in attention, verbal and motor initiative and conceptual thinking than the MCI patients, while in verbal memory the MCI patients were more impaired. According to a discriminant analysis, half of BD sample reported deficits similar to the MCI group in verbal memory and a higher functional impairment. Conclusions: Patients with BD and patients with MCI have distinct profiles of cognitive impairment. In spite of these neuropsychological differences, both groups presented similar recent memory complaints and functional impairments. Moreover, from the present results a subgroup of BD patients with recent cognitive complaints may actually suffer from concomitant incipient MCI, and this finding may have diagnostic and therapeutical implications.
Autores principais:Silva, Dina Lúcia Gomes da, 1981-
Assunto:Transtorno bipolar Defeito cognitivo ligeiro Avaliação neuropsicológica Pessoas de meia-idade Idosos Queixas cognitivas Teses de mestrado - 2008
Ano:2008
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso restrito
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa

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