Publicação
Granulomatose com poliangeíte
| Resumo: | Vasculitides are systemic diseases characterised by the presence of vascular inflammation. They can be classified according to the American College of Rheumatology Criteria and to the Chapel Hill Consensus Conference Nomenclature of Vasculitides. These do not enable to make the diagnosis, but to place the patients in diagnostic subgroups. The diagnosis is given by a compatible fenotype, specific serology or imagiology and confirmation is set by biopsy. There are different scores that allow the measurement of the severity and damage caused by vasculitides. Granulomatosis with Polyangiitis is an auto-imune disease characterised by granulomatous inflammation of the respiratory airways and renal and pulmonary small vessel vasculitis. It is more common among caucasians and white male in Europe. The symptoms usually start between the ages of 45 and 65. It is associated with the presence of antineutrophil cytoplasmic antibodies (ANCA) aginst proteinase 3, yet its etiology is still unknown. The treatment is based on stage and disease activity. In severe disease it is administrated cyclophosphamide with glucocorticoids, which are then changed to less potent imunosupressors after the induction of remission. There are new biological therapies under investigation. |
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| Autores principais: | Gomes, Margarida A. Pereira |
| Assunto: | ANCA associated vasculites Wegener’s granulomatosis Granulomatosis with polyangiitis |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Vasculitides are systemic diseases characterised by the presence of vascular inflammation. They can be classified according to the American College of Rheumatology Criteria and to the Chapel Hill Consensus Conference Nomenclature of Vasculitides. These do not enable to make the diagnosis, but to place the patients in diagnostic subgroups. The diagnosis is given by a compatible fenotype, specific serology or imagiology and confirmation is set by biopsy. There are different scores that allow the measurement of the severity and damage caused by vasculitides. Granulomatosis with Polyangiitis is an auto-imune disease characterised by granulomatous inflammation of the respiratory airways and renal and pulmonary small vessel vasculitis. It is more common among caucasians and white male in Europe. The symptoms usually start between the ages of 45 and 65. It is associated with the presence of antineutrophil cytoplasmic antibodies (ANCA) aginst proteinase 3, yet its etiology is still unknown. The treatment is based on stage and disease activity. In severe disease it is administrated cyclophosphamide with glucocorticoids, which are then changed to less potent imunosupressors after the induction of remission. There are new biological therapies under investigation. |
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