Publicação
BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single
| Resumo: | Aims: To evaluate the efficacy and safety of the treatment of psoriatic arthritis (PsA) patients with tumor necrosis factor (TNF) antagonists in the Rheumatology Department of Hospital de Santa Maria using the BioRePortAP. Methods: The Portuguese Society of Rheumatology (SPR) developed an electronic medical chart coupled with a database for the follow up of PsA patients, the BioRePortAP, which was launched in May 2009. This evaluation was based on all the PsA patients that were on active treatment with TNF antagonists in September 2009 and were registered in the BioRePortAP. All the previous data on these patients were introduced in BioRePortAP using the prospective paper based follow up protocol that this Department was using since 1999. Only patients with more than 9 months of treatment were analyzed. Results: Forty-two patients with PsA, actively treated with anti-TNF agents in September 2009, for at least 9 months, were analyzed in BioRePortAP. Twenty-three patients were male (55%) and nineteen were female (45%). The average age of these patients was 49.8±10.9 years old, the average disease duration was of 10.7±5.6 years and the mean duration of biological therapy was of 37.8±27.8 months. For the 81% of patients with peripheral joint disease there was a mean reduction of more than 80% in the swollen and tender joint counts, and almost 50% in the health assessment questionnaire (HAQ) value. In the 19% of the patients with axial involvement the reduction of BASDAI and BASFI was not statistically significative. On top of that, PASI score suffered a reduction of 64%. Fourteen patients (33.3%) had to switch their TNF antagonist treatment. 58.8% of the switches were due to adverse effects and 41.2% due to therapy failure. Regarding the 56 adverse reactions registered, only one was a severe reaction. The remaining adverse reactions were not severe and 67% of them were due to infections. Discussion: The results of this first report of the use of the BioRePortAP in clinical practice confirm the efficacy and safety of TNF antagonist treatment in PsA. The results shown here elucidate the potential applications of BioRePortAP as a tool for efficacy and safety assessment of PsA patients treated with biotechnological drugs. |
|---|---|
| Autores principais: | Campanilho-Marques, R. |
| Outros Autores: | Polido-Pereira, J.; Rodrigues, A.; Ramos, F.; Saavedra, M. J.; Costa, M.; Martins, F.; Pereira da Silva, José A.; Canhao, Helena; Fonseca, João Eurico |
| Assunto: | Psoriatic arthritis Registry BioReportAP Biological therapy Portugal |
| Ano: | 2010 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866809995523260416 |
|---|---|
| author | Campanilho-Marques, R. |
| author2 | Polido-Pereira, J. Rodrigues, A. Ramos, F. Saavedra, M. J. Costa, M. Martins, F. Pereira da Silva, José A. Canhao, Helena Fonseca, João Eurico |
| author2_role | author author author author author author author author author |
| author_facet | Campanilho-Marques, R. Polido-Pereira, J. Rodrigues, A. Ramos, F. Saavedra, M. J. Costa, M. Martins, F. Pereira da Silva, José A. Canhao, Helena Fonseca, João Eurico |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Campanilho-Marques, R.\"},{\"Person.name\":\"Polido-Pereira, J.\"},{\"Person.name\":\"Rodrigues, A.\"},{\"Person.name\":\"Ramos, F.\"},{\"Person.name\":\"Saavedra, M. J.\"},{\"Person.name\":\"Costa, M.\"},{\"Person.name\":\"Martins, F.\"},{\"Person.name\":\"Pereira da Silva, José A.\"},{\"Person.name\":\"Canhao, Helena\",\"Person.identifier.orcid\":\"0000-0002-3239-2809\"},{\"Person.name\":\"Fonseca, João Eurico\",\"Person.identifier.orcid\":\"0000-0003-1432-3671\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Campanilho-Marques, R. Polido-Pereira, J. Rodrigues, A. Ramos, F. Saavedra, M. J. Costa, M. Martins, F. Pereira da Silva, José A. Canhao, Helena Fonseca, João Eurico |
| datacite.date.Accepted.fl_str_mv | 2010-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2012-05-03T15:03:57Z |
| datacite.date.embargoed.fl_str_mv | 2012-05-03T15:03:57Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Psoriatic arthritis Registry BioReportAP Biological therapy Portugal |
| datacite.titles.title.fl_str_mv | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Campanilho-Marques, R. Polido-Pereira, J. Rodrigues, A. Ramos, F. Saavedra, M. J. Costa, M. Martins, F. Pereira da Silva, José A. Canhao, Helena Fonseca, João Eurico |
| dc.date.Accepted.fl_str_mv | 2010-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2012-05-03T15:03:57Z |
| dc.date.embargoed.fl_str_mv | 2012-05-03T15:03:57Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/6203 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Reumatologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Psoriatic arthritis Registry BioReportAP Biological therapy Portugal |
| dc.title.fl_str_mv | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Aims: To evaluate the efficacy and safety of the treatment of psoriatic arthritis (PsA) patients with tumor necrosis factor (TNF) antagonists in the Rheumatology Department of Hospital de Santa Maria using the BioRePortAP. Methods: The Portuguese Society of Rheumatology (SPR) developed an electronic medical chart coupled with a database for the follow up of PsA patients, the BioRePortAP, which was launched in May 2009. This evaluation was based on all the PsA patients that were on active treatment with TNF antagonists in September 2009 and were registered in the BioRePortAP. All the previous data on these patients were introduced in BioRePortAP using the prospective paper based follow up protocol that this Department was using since 1999. Only patients with more than 9 months of treatment were analyzed. Results: Forty-two patients with PsA, actively treated with anti-TNF agents in September 2009, for at least 9 months, were analyzed in BioRePortAP. Twenty-three patients were male (55%) and nineteen were female (45%). The average age of these patients was 49.8±10.9 years old, the average disease duration was of 10.7±5.6 years and the mean duration of biological therapy was of 37.8±27.8 months. For the 81% of patients with peripheral joint disease there was a mean reduction of more than 80% in the swollen and tender joint counts, and almost 50% in the health assessment questionnaire (HAQ) value. In the 19% of the patients with axial involvement the reduction of BASDAI and BASFI was not statistically significative. On top of that, PASI score suffered a reduction of 64%. Fourteen patients (33.3%) had to switch their TNF antagonist treatment. 58.8% of the switches were due to adverse effects and 41.2% due to therapy failure. Regarding the 56 adverse reactions registered, only one was a severe reaction. The remaining adverse reactions were not severe and 67% of them were due to infections. Discussion: The results of this first report of the use of the BioRePortAP in clinical practice confirm the efficacy and safety of TNF antagonist treatment in PsA. The results shown here elucidate the potential applications of BioRePortAP as a tool for efficacy and safety assessment of PsA patients treated with biotechnological drugs. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/718c5736-d7c9-483c-9845-8685b42d88a1/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10451/6203 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/6203 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Campanilho-Marques, R. Polido-Pereira, J. Rodrigues, A. Ramos, F. Saavedra, M. J. Costa, M. Martins, F. Pereira da Silva, José A. Canhao, Helena Canhao, Helena http://orcid.org/0000-0002-3239-2809 0000-0002-3239-2809 Fonseca, João Eurico Fonseca, João Eurico https://www.ciencia-id.pt/F310-B85D-57C7 F310-B85D-57C7 http://orcid.org/0000-0003-1432-3671 0000-0003-1432-3671 |
| publishDate | 2010 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Reumatologia |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
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| spelling | engSociedade Portuguesa de ReumatologiaengAims: To evaluate the efficacy and safety of the treatment of psoriatic arthritis (PsA) patients with tumor necrosis factor (TNF) antagonists in the Rheumatology Department of Hospital de Santa Maria using the BioRePortAP. Methods: The Portuguese Society of Rheumatology (SPR) developed an electronic medical chart coupled with a database for the follow up of PsA patients, the BioRePortAP, which was launched in May 2009. This evaluation was based on all the PsA patients that were on active treatment with TNF antagonists in September 2009 and were registered in the BioRePortAP. All the previous data on these patients were introduced in BioRePortAP using the prospective paper based follow up protocol that this Department was using since 1999. Only patients with more than 9 months of treatment were analyzed. Results: Forty-two patients with PsA, actively treated with anti-TNF agents in September 2009, for at least 9 months, were analyzed in BioRePortAP. Twenty-three patients were male (55%) and nineteen were female (45%). The average age of these patients was 49.8±10.9 years old, the average disease duration was of 10.7±5.6 years and the mean duration of biological therapy was of 37.8±27.8 months. For the 81% of patients with peripheral joint disease there was a mean reduction of more than 80% in the swollen and tender joint counts, and almost 50% in the health assessment questionnaire (HAQ) value. In the 19% of the patients with axial involvement the reduction of BASDAI and BASFI was not statistically significative. On top of that, PASI score suffered a reduction of 64%. Fourteen patients (33.3%) had to switch their TNF antagonist treatment. 58.8% of the switches were due to adverse effects and 41.2% due to therapy failure. Regarding the 56 adverse reactions registered, only one was a severe reaction. The remaining adverse reactions were not severe and 67% of them were due to infections. Discussion: The results of this first report of the use of the BioRePortAP in clinical practice confirm the efficacy and safety of TNF antagonist treatment in PsA. The results shown here elucidate the potential applications of BioRePortAP as a tool for efficacy and safety assessment of PsA patients treated with biotechnological drugs.application/pdfengBioRePortAP, an electronic clinical record coupled with a database : an example of its use in a singleCampanilho-Marques, R.Polido-Pereira, J.Rodrigues, A.Ramos, F.Saavedra, M. J.Costa, M.Martins, F.Pereira da Silva, José A.PersonalCanhao, HelenaDSpacehttp://dspace.org/items/48f3be39-37f9-44de-9c7e-22e49a89efe5DSpacehttp://dspace.org/items/48f3be39-37f9-44de-9c7e-22e49a89efe5CanhaoHelenaORCIDhttp://orcid.org0000-0002-3239-2809Scopus Author IDhttps://www.scopus.com6602393492PersonalFonseca, João EuricoDSpacehttp://dspace.org/items/1772dc12-7c55-4c76-ae2d-c23270172480DSpacehttp://dspace.org/items/1772dc12-7c55-4c76-ae2d-c23270172480FonsecaJoãoCiência IDhttps://www.ciencia-id.ptF310-B85D-57C7ORCIDhttp://orcid.org0000-0003-1432-3671Scopus Author IDhttps://www.scopus.com7101983519Scopus Author IDhttps://www.scopus.com55881559500HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptURLhttp://arp.spreumatologia.pt/download.php?filename=ARP_2010_2_176_11__AO_-_BioReportAR_ARP2010_58AO.pdfISSNIsPartOf0303-464X2012-05-03T15:03:57Z20102010-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/6203http://purl.org/coar/access_right/c_abf2open accessPsoriatic arthritisRegistryBioReportAPBiological therapyPortugal105711 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/718c5736-d7c9-483c-9845-8685b42d88a1/downloadActa Reumatologica Portuguesa176183 |
| spellingShingle | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single Campanilho-Marques, R. Psoriatic arthritis Registry BioReportAP Biological therapy Portugal |
| status | SINGLETON |
| subject.fl_str_mv | Psoriatic arthritis Registry BioReportAP Biological therapy Portugal |
| title | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single |
| title_full | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single |
| title_fullStr | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single |
| title_full_unstemmed | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single |
| title_short | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single |
| title_sort | BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single |
| topic | Psoriatic arthritis Registry BioReportAP Biological therapy Portugal |
| topic_facet | Psoriatic arthritis Registry BioReportAP Biological therapy Portugal |
| url | http://hdl.handle.net/10451/6203 |
| visible | 1 |