A requirement for the abnormal spindle protein to organise microtubules of the central spindle for cytokinesis in drosophila

• Autor(es): Riparbelli, Maria Giovanna ; Callaini, Giuliano ; Glover, David M. ; Avides, Maria do Carmo
• Data: 2004
• Identificador Persistente: http://hdl.handle.net/10284/10312
• Origem: Repositório Institucional - Universidade Fernando Pessoa
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Institucional da Fernando Pessoa

Descrição

Drosophila abnormal spindle (asp) mutants exhibit a mitotic metaphase checkpoint arrest with abnormal spindle poles, which reflects a requirement for Asp for the integrity of microtubule organising centres. In male meiosis, the absence of a strong spindle integrity checkpoint enables asp mutant cells to proceed through telophase. However, the central spindle region is not correctly organised and cells frequently fail to complete cytokinesis. We speculate that Asp is associated with the minus ends of microtubules that have been released from the spindle poles to form the central spindle.