Author(s): Ullah, Hammad ; Khan, Haroon ; Prieto Lage, Miguel A. ; Daglia, Maria
Date: 2024
Persistent ID: http://hdl.handle.net/10198/29721
Origin: Biblioteca Digital do IPB
Subject(s): Natural products; Herbal medicines (HM); Aging; Age related disorders; Prevention
The population aged ≥60 years is growing worldwide. The World Health Organization (WHO) reported that the elderly population is expected to increase from 1 billion in 2020 to 1.4 billion in 2030 and 2.1 billion in 2050 (World Health Organization, 2022). This increase in life expectancy around the globe is accompanied with the enhancing frequency of agingassociated disorders, mainly due to the deterioration of metabolic, circulatory, and immune functioning. Inflammaging (chronic low-grade inflammation) is considered as one of the main drivers of the initiation and progression of diseases such as sarcopenia, osteoporosis, metabolic ailments, atherosclerosis, neurodegenerations, and carcinogenesis (Ullah et al., 2022). However, the actual etiology of these disorders is complicated due to the complex interaction of genes and environment, making their management more challenging in realworld circumstances. Currently, pharmacological interventions remained the mainstream option for the treatment of age-related diseases although drugs are associated with increased risk of the occurrence of adverse effects due to the increased susceptibility of adult population to drug effects, altered pharmacokinetic parameters, and use of polypharmacy, which may also increase the likelihood of drug interactions (Baldoni et al., 2010; Goldberg et al., 2022; Kwak et al., 2022).
