RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population

• Author(s): Freitas, Ana I ; Mendonça, Isabel ; Brión, Maria ; Sequeira, Miguel M ; Reis, Roberto P ; Carracedo, Angel ; Brehm, António
• Date: 2008
• Persistent ID: http://hdl.handle.net/10400.26/28008
• Origin: Serviço de Saúde da Região Autónoma da Madeira, E.P.E.
• Subject(s): Angiotensinogen; Coronary Artery Disease; Gene Frequency; Genes, RAS; Genetic Predisposition to Disease; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Portugal; Risk Factors; Madeira
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Comum

Description

Several polymorphisms within the renin-angiotensin system cluster of genes have been associated with the advent of coronary artery disease (CAD) or related pathologies. We investigated the distribution of 5 of these polymorphisms in order to find any association with CAD development and distinguish if any of the biochemical and behavioural factors interact with genetic polymorphisms in the advent of the disease.