Autor(es): Teodoro, João S. ; Silva, Rui T. da ; Machado, Ivo ; Panisello-Roselló, Arnau ; Roselló-Catafau, Joan ; Rolo, Anabela P. ; Palmeira, Carlos M.
Data: 2022
Identificador Persistente: https://hdl.handle.net/10316/103217
Origem: Estudo Geral - Universidade de Coimbra
Assunto(s): mitochondria; liver; ischemia/reperfusion; liver surgery; conditioning; Animals; Disease Models, Animal; Ischemia; Mitochondria; Reperfusion; Liver Diseases; Reperfusion Injury
Hepatic ischemia reperfusion injury (HIRI) is a major hurdle in many clinical scenarios, including liver resection and transplantation. Various studies and countless surgical events have led to the observation of a strong correlation between HIRI induced by liver transplantation and early allograft-dysfunction development. The detrimental impact of HIRI has driven the pursuit of new ways to alleviate its adverse effects. At the core of HIRI lies mitochondrial dysfunction. Various studies, from both animal models and in clinical settings, have clearly shown that mitochondrial function is severely hampered by HIRI and that its preservation or restoration is a key indicator of successful organ recovery. Several strategies have been thus implemented throughout the years, targeting mitochondrial function. This work briefly discusses some the most utilized approaches, ranging from surgical practices to pharmacological interventions and highlights how novel strategies can be investigated and implemented by intricately discussing the way mitochondrial function is affected by HIRI.
This work was financed by the European Regional Development Fund (ERDF), through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization and Portuguese National Funds via FCT—Fundação para a Ciência e a Tecnologia, under project UIDB/04539/2020 and UIDP/04539/2020. JST is recipient of a CEEC researcher grant from FCT and CNC(CEECIND/4400/2007). IFM is recipient of a PhD scholarship from FCT (DFA/BD/8529/2020). RTS was a recipient of a Foie Gras Early Research Training Grant, from the European Union’s Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant (Agreement No. 722619).
