Author(s):
Okubadejo, Njideka ; Britton, Angela ; Crews, Cynthia ; Akinyemi, Rufus ; Hardy, John ; Singleton, Andrew ; Brás, José
Date: 2008
Persistent ID: https://hdl.handle.net/10316/110856
Origin: Estudo Geral - Universidade de Coimbra
Subject(s): Adult; Aged; Ataxin-3; Case-Control Studies; Cohort Studies; DNA Mutational Analysis; Female; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Nerve Tissue Proteins; Nigeria; Nuclear Proteins; Parkinson Disease; Protein Serine-Threonine Kinases; Repressor Proteins; Ubiquitin-Protein Ligases; Mutation
Description
Several genetic variations have been associated with Parkinson disease in different populations over the past few years. Although a considerable number of worldwide populations have been screened for these variants, results from Sub-Saharan populations are very scarce in the literature. In the present report we have screened a cohort of Parkinson disease patients (n = 57) and healthy controls (n = 51) from Nigeria for mutations in the genes PRKN, LRRK2 and ATXN3. No pathogenic mutations were found in any of the genes. Hence, common pathogenic mutations in these genes, observed in several different populations, are not a frequent cause of Parkinson disease in Nigeria.
