Autor(es): Esteves, A. Raquel ; Munoz-Pinto, Mário F. ; Nunes-Costa, Daniela ; Candeias, Emanuel ; Silva, Diana F. ; Magalhães, João D. ; Pereira-Santos, A. Raquel ; Ferreira, I. Luisa ; Alarico, Susana ; Tiago, Igor ; Empadinhas, Nuno ; Cardoso, Sandra Morais
Data: 2021
Identificador Persistente: https://hdl.handle.net/10316/96599
Origem: Estudo Geral - Universidade de Coimbra
Assunto(s): Gut inflammation; Intestinal bacteria; Intestinal barrier function; Neurobiology
Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N-methylamino-L-alanine (BMAA) in the gut may trigger some PD cases, which is especially worrying as this toxin is present in certain foods but not routinely monitored by public health authorities.
This work was funded by Santa Casa da Misericórdia de Lisboa, Portugal, through Mantero Belard Neurosciences Prize 2016 (MB-40-2016); by FMUCPEPITA (2018); by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0145-FEDER-000012 (HealthyAging 2020) and through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalization and by Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia under projects PTDC/MED-NEU/3644/2020, PINFRA/22184/2016/POCI-01-0145-FEDER-022184 and UIDB/04539/2020. EC was supported by fellowship MB-40-2016. IT was supported by IF/01061/2014 Investigator contract. JDM is supported by PhD fellowship PD/BD/146409/2019, DN-C is supported by PhD fellowship SFRH/BD
