Autor(es): Campos, Maria Jorge ; Palomo, Gonzalo ; Hormeño, Lorena ; Rodrigues, Américo ; Sánchez-Benito, Rosario ; Píriz, Segundo ; Quesada, Alberto
Data: 2015
Identificador Persistente: http://hdl.handle.net/10400.8/14132
Origem: IC-online
Assunto(s): Citrobacter freundii; Drug Resistance; Humans; Molecular Sequence Data; Quinolones
LETTER Quinolone resistance in Enterobacteriaceae is mediated by mutations in the quinolone resistance-determining regions (QRDR) of topoisomerase genes and/or by plasmid-mediated quinolone resistance determinants (PMQR) such as the qnr genes encoding pentapeptide repeat proteins (1). The qnrB family is represented by 80 different alleles (http://www.lahey.org/qnrStudies/); most of them originated from Citrobacter strains and spread to other Enterobacteriaceae species (2). This work describes the identification of a new allele of the quinolone resistance protein QnrB, QnrB54, in a human clinical isolate of Citrobacter freundii detected in Spain.
