Author(s): Rocha, Felipe Filardi da ; Diniz, Leandro Malloy ; Sousa, Karla Cristhina Alves de ; Cano Prais, Hugo Alejandro ; Correa, Humberto ; Teixeira, Antônio Lúcio
Date: 2014
Origin: Oasisbr
Subject(s): Schizencephaly; Impulsivity; Borderline personality; Orbitofrontal cortex; Cingulate cortex
Prefrontal cortex dysfunction has been associated with a series of behavioral symptoms, such as impulsivity and affective instability, which are the defining features of several personality disorders, notably, borderline personality disorder. We report on a 27-year-old patient with schizencephaly in the right frontal lobe (cingulate cortex lesion and secondary orbitofrontal cortex dysfunction) presenting with prominent borderline features and compromise of executive functions, decision-making and attention. We hypothesize that the personality disorder of our patient could be related to cingulate cortex lesion and secondary orbitofrontal cortex dysfunction associated with schizencephaly.
