Autor(es): Nunes, M?rcio Roberto Teixeira ; Palacios, Gustavo ; Faria, Nuno Rodrigues ; Sousa Junior, Edivaldo Costa ; Pantoja, Jamilla A ; Rodrigues, Sueli Guerreiro ; Carvalho, Val?ria Lima ; Medeiros, Daniele Barbosa de Almeida ; Savji, Nazir ; Baele, Guy ; Suchard, Marc A ; Lemey, Philippe ; Vasconcelos, Pedro Fernando da Costa ; Lipkin, W. Ian
Data: 2016
Origem: Oasisbr
Assunto(s): V?rus da Dengue / isolamento & purifica??o; Estruturas Gen?ticas
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
United States Army Medical Research Institute for Infectious Diseases. Center for Genomic Sciences. Maryland, USA / Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, USA.
University of Oxford. Department of Zoology. Oxford, United Kingdom.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, USA.
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, USA.
University of Oxford. Department of Zoology. Oxford, United Kingdom.
University of Oxford. Department of Zoology. Oxford, United Kingdom.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Par?. Bel?m, PA, Brazil.
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, USA.
Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
