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Zika virus in the Americas: early epidemiological and genetic findings

Author(s): Faria, Nuno Rodrigues ; Azevedo, Raimunda do Socorro da Silva ; Kraemer, Moritz U. G ; Souza, Renato ; Cunha, Mariana Sequetin ; Hill, Sarah C ; Th?z?, Julien ; Bonsall, Michael B ; Bowden, Thomas A ; Rissanen, Ilona ; Rocco, Iray Maria ; Nogueira, Juliana Silva ; Maeda, Adriana Yurika ; Vasami, Fernanda Giseli da Silva ; Macedo, Fernando Luiz de Lima ; Suzuki, Akemi ; Rodrigues, Sueli Guerreiro ; Cruz, Ana Cec?lia Ribeiro ; Nunes, Bruno Tardeli ; Medeiros, Daniele Barbosa de Almeida ; Rodrigues, Daniela Sueli Guerreiro ; Queiroz, Alice Louize Nunes ; Silva, Eliana Vieira Pinto da ; Henriques, Daniele Freitas ; Rosa, Elizabeth Salb? Travassos da ; Oliveira, Consuelo Silva de ; Martins, L?via Caricio ; Vasconcelos, Helena Baldez ; Casseb, Livia Medeiros Neves ; Simith, Darlene de Brito ; Messina, Jane P ; Abade, Leandro ; Louren?o, Jos? ; Alc?ntara, Luiz Carlos Junior ; Lima, Maric?lia Maia de ; Giovanetti, Marta ; Hay, Simon I ; Oliveira, Rodrigo Santos de ; Lemos, Poliana da Silva ; Oliveira, Layanna Freitas de Oliveira ; Lima, Clayton Pereira Silva de ; Silva, Sandro Patroca da ; Vasconcelos, Janaina Mota de ; Franco, Luciano ; Cardoso, Jedson Ferreira ; Vianez J?nior, Jo?o L?dio da Silva Gon?alves ; Mir, Daiana ; Bello, Gonzalo ; Delatorre, Edson ; Khan, Kamran ; Creatore, Marisa ; Coelho, Giovanini Evelim ; Oliveira, Wanderson Kleber de ; Tesh, Robert ; Pybus, Oliver G ; Nunes, M?rcio Roberto Teixeira ; Vasconcelos, Pedro Fernando da Costa

Date: 2017

Origin: Oasisbr

Subject(s): Zika V?rus; Epidemiologia; Gen?tica; Microcefalia; Malforma??es cong?nitas; Zika virus / gen?tica; Infec??o pelo Zika virus / transmiss?o; Microcefalia / embriologia; Evolu??o Molecular; Genoma Viral; Brasil / epidemiologia

Description

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro de Inova??es Tecnol?gicas. Ananindeua, PA, Brazil / University of Oxford. Department of Zoology. Oxford, UK.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

University of Oxford. Department of Zoology. Oxford, UK.

Universidade de S?o Paulo. Instituto Adolfo Lutz. S?o Paulo, SP, Brasil.

University of Oxford. Department of Zoology. Oxford, UK.

University of Oxford. Wellcome Trust Centre for Human Genetics. Oxford, UK.

Universidade de S?o Paulo. Instituto Adolfo Lutz. S?o Paulo, SP, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

University of Oxford. Department of Zoology. Oxford, UK / Metabiota. San Francisco, CA 94104, USA.

University of Oxford. Department of Zoology. Oxford, UK.

Funda??o Oswaldo Cruz. Salvador, BA, Brasil.

Universidade Estadual de Feira de Santana, Feira de Santana. Departamento de Sa?de. Centro de P?s-Gradua??o em Sa?de Coletiva. Feira de Santana, BA, Brasil.

Funda??o Oswaldo Cruz. Salvador, BA, Brasil.

University of Washington. Institute for Health Metrics and Evaluation,. Seattle, WA, USA / University of Oxford. Wellcome Trust Centre for Human Genetics. Oxford, UK.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro de Inova??es Tecnol?gicas. Ananindeua, PA, Brasil

Funda??o Oswaldo Cruz. Instituto Oswaldo Cruz. Laborat?rio de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.

Li Ka Shing Knowledge Institute. St. Michael?s Hospital. Toronto, Canada / University of Toronto. Department of Medicine. Division of Infectious Diseases. Toronto, Canada.

University of Toronto.Dalla Lana School of Public Health. Toronto, Canada;

Brasil. Minist?rio da Sa?de. Bras?lia, DF, Brasil.

University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.

University of Oxford. Department of Zoology. Oxford, UK / Metabiota. San Francisco, CA 94104, USA.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas, Centro de Inova??o tecnol?gica. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil

Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015 and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. Using next generation sequencing we generated seven Brazilian ZIKV genomes, sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, estimated to have occurred between May-Dec 2013, more than 12 months prior to the detection of ZIKV in Brazil. The estimated date of origin coincides with an increase in air passengers to Brazil from ZIKV endemic areas, and with reported outbreaks in Pacific Islands. ZIKV genomes from Brazil are phylogenetically interspersed with those from other South American and Caribbean countries. Mapping mutations onto existing structural models revealed the context of viral amino acid changes present in the outbreak lineage; however no shared amino acid changes were found among the three currently available virus genomes from microcephaly cases. Municipality-level incidence data indicate that reports of suspected microcephaly in Brazil best correlate with ZIKV incidence around week 17 of pregnancy, although this does not demonstrate causation. Our genetic description and analysis of ZIKV isolates in Brazil provide a baseline for future studies of the evolution and molecular epidemiology in the Americas of this emerging virus.

Document Type Journal article
Language English

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Zika virus in the Americas: early epidemiological and genetic findings

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