Author(s):
Ros?rio, Mateus Santana do ; Giovanetti, Marta ; Jesus, Pedro Antonio Pereira de ; Farias, Daniel Santana ; Faria, Nuno R ; LIma, Clayton Pereira S. de ; Silva, Sandro Patroca da ; Nunes, Marcio Roberto Teixeira ; Alc?ntara, Luiz Carlos Junior ; Siqueira, Isadora Cristina de
Date: 2018
Origin: Oasisbr
Subject(s): Opsoclonus; V?rus Chikungunya / patogenicidade; V?rus da Dengue / patogenicidade; S?ndromes Paraneopl?sicas do Sistema Nervoso; Transtornos da Motilidade Ocular; Ataxia; Mioclonia; Coinfec??o / virologia; Vigil?ncia
Description
CNPq-National Council for Scientific and Technological Development (302584/2015-3) and MCTI-Ministry of Science, Technology, Innovation/FINEP?Funding Authority for Studies and Projects/FNDCT?National Fund for the Development of Science and Technology (04160060-00/2016)
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brasil / Secretaria Estadual da Sa?de da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brasil / University of Rome Tor Vergata. Rome, Italy.
Secretaria Estadual da Sa?de da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
Secretaria Estadual da Sa?de da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
University of Oxford. Department of Zoology. Oxford, UK.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro de Tecnologia e Inova??o. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro de Tecnologia e Inova??o. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro de Tecnologia e Inova??o. Ananindeua, PA, Brasil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brasil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brasil.
Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare neurological disorder characterized by irregular multidirectional eye movements, myoclonus, cerebellar ataxia, sleep disturbances, and cognitive dysfunction. Although most commonly related to paraneoplastic syndrome, this condition has occasionally been described following infectious illnesses. This article reports the first case of OMAS in association with chikungunya and dengue virus co-infection. The genetic analysis identified chikungunya virus of East/Central/South African genotype and dengue serotype 4 virus of genotype II. This report represents an unusual clinical syndrome associated with viral co-infection and reinforces the need for clinical vigilance with regard to neurological syndromes in the context of emergent arboviruses.
