Autor(es):
Santos, Leonardo Miranda dos ; Vieira, Maria Renata Mendon?a dos Santos ; Oliveira, J?ssica Fernanda Galdino ; Trindade, Josinaide Quaresma ; Brasiliense, Danielle Murici ; Ferrari, Stephen Francis ; Tsutsumi, Mihoko Yamamoto ; Fuzii, Hellen Thais ; Sousa J?nior, Edivaldo Costa ; Ishikawa, Edna Aoba Yassui ; Ishak, Ricardo ; Sousa, Ma?sa Silva de
Data: 2018
Origem: Oasisbr
Assunto(s): Chlamydia trachomatis / patogenicidade; Infec??es por Chlamydia; Infec??es por Chlamydia / virologia; Comportamento Sexual; Doen?as Bacterianas Sexualmente Transmiss?veis; Assist?ncia ? Sa?de; Arquip?lago do Maraj? (PA)
Descrição
The present study was fully supported by grants from the Fundac??o Amazo?nia Paraense de Amparo a Pesquisa (FAPESPA ? ICAAF 014/2012) and Ministe?rio da Sau?de do Brasil (MS).
Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Biologia Molecular e Celular. Bel?m, PA, Brasil / Universidade Federal do Par?. Programa de P?s-gradua??o em Doen?as Tropicais. Bel?m, PA, Brasil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Biologia Molecular e Celular. Bel?m, PA, Brasil / Universidade Federal do Par?. Programa de P?s-gradua??o em An?lises Cl?nicas. Bel?m, PA, Brasil.
Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Citopatologia. Bel?m, PA, Brasil.
Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Citopatologia. Bel?m, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Universidade Federal do Sergipe. Departamento de Ecologia. S?o Crist?v?o, SE, Brasil.
Universidade Federal do Par?. Programa de P?s-gradua??o em An?lises Cl?nicas. Bel?m, PA, Brasil / Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Citopatologia. Bel?m, PA, Brasil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Imunopatologia. Bel?m, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Biologia Molecular e Celular. Bel?m, PA, Brasil.
Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brasil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Biologia Molecular e Celular. Bel?m, PA, Brasil.
BACKGROUND: Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection (STI) in the world. Approximately 80% of infected women are asymptomatic, although this infection can lead to serious complications in the female reproductive tract. Few data on Chlamydia infection are available in rural Amazonian communities. OBJECTIVES: To evaluate the prevalence of sexual C. trachomatis infection in women from Maraj? Archipelago communities in the Amazon region of Brazil and to identify associated factors and genotypes. METHODS: We utilized amplification of the ompA gene by nested PCR. Positive samples were genotyped by sequencing. Study participants completed a questionnaire on social, epidemiological, and reproductive health variables. A Poisson regression was used to evaluate the degree of association of these variables with the infection. RESULTS: The sexual infection by C. trachomatis was observed in 4% (16/393) of the subjects, and was more often found in women aged ?25 (14.3%; 95% CI = 2.83-35.47; p <0.001), and in women with a household income of less than one Brazilian monthly minimum wage (5.2%; 95% CI = 1.33-11.37; p = 0.014). The ompA gene was sequenced in 13 samples, revealing F genotypes (38.4%, n = 5), D (23%, n = 3), E (15.3%, n = 2), Ia (7.6%, N = 1), J (7.6%, n = 1) and B (7.6%, n = 1). CONCLUSIONS: We recorded a high prevalence of sexual infection by C. trachomatis in young and poor women from the interior of the Brazilian Amazon. This high prevalence and the frequencies of the main genotypes were similar to those found in major Brazilian urban centers. Our results reinforce the importance of the screening of this neglected infection, and the prevention of later sequelae in young women from rural and urban areas of Brazil.
