Phylogeography of dengue virus serotype 4, Brazil, 2010-2011

• Autor(es): Nunes, M?rcio Roberto Teixeira ; Faria, Nuno Rodrigues ; Vasconcelos, Helena Baldez ; Medeiros, Daniele Barbosa de Almeida ; Lima, Clayton Pereira Silva de ; Carvalho, Val?ria Lima ; Silva, Eliana Vieira Pinto da ; Cardoso, Jedson Ferreira ; Sousa Junior, Edivaldo Costa ; Nunes, Keley Nascimento Barbosa ; Rodrigues, Sueli Guerreiro ; Abecasis, Ana Barroso ; Suchard, Marc A ; Lemey, Philippe ; Vasconcelos, Pedro Fernando da Costa
• Data: 2016
• Origem: Oasisbr
• Assunto(s): V?rus da Dengue / isolamento & purifica??o; Dengue / transmiss?o; Gen?tipo; Brasil (BR)
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Katholieke Universiteit Leuven. Leuven, Belgium.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Universidade Nova de Lisboa. Lisbon, Portugal.

University of Calif?rnia. Los Angeles, Calif?rnia, USA.

Katholieke Universiteit Leuven. Leuven, Belgium.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Universidade do Estado do Par?. Bel?m, PA, Brasil.

Dengue virus serotype 4 (DENV-4) reemerged in Roraima State, Brazil, 28 years after it was last detected in the country in 1982. To study the origin and evolution of this reemergence, full-length sequences were obtained for 16 DENV-4 isolates from northern (Roraima, Amazonas, Par? States) and northeastern (Bahia State) Brazil during the 2010 and 2011 dengue virus seasons and for an isolate from the 1982 epidemic in Roraima. Spatiotemporal dynamics of DENV-4 introductions in Brazil were applied to envelope genes and full genomes by using Bayesian phylogeographic analyses. An introduction of genotype I into Brazil from Southeast Asia was confirmed, and full genome phylogeographic analyses revealed multiple introductions of DENV-4 genotype II in Brazil, providing evidence for %>3 introductions of this genotype within the last decade: 2 from Venezuela to Roraima and 1 from Colombia to Amazonas. The phylogeographic analysis of full genome data has demonstrated the origins of DENV-4 throughout Brazil.