17DD Yellow Fever revaccination and heightened long-term immunity in populations of disease-endemic areas, Brazil

• Author(s): Campi-Azevedo, Ana Carolina ; Peruhype-Magalh?es, Vanessa ; Coelho-dos-Reis, Jordana Grazziela ; Antonelli, Lis Ribeiro ; Costa-Pereira, Christiane ; Speziali, Eliane ; Reis, Laise Rodrigues ; Lemos, Jandira Aparecida ; Ribeiro, Jos? Geraldo Leite ; Camacho, Luiz Ant?nio Bastos ; Maia, Maria de Lourdes de Sousa ; Lima, Sheila Maria Barbosa de ; Sim?es, Marisol ; Martins, Reinaldo de Menezes ; Homma, Akira ; Malaquias, Luiz Cosme Cota ; Tauil, Pedro Luiz ; Vasconcelos, Pedro Fernando da Costa ; Romano, Alessandro Pecego Martins ; Domingues, Carla Magda ; Teixeira-Carvalho, Andr?a ; Martins-Filho, Olindo Assis
• Date: 2019
• Origin: Oasisbr
• Subject(s): Febre Amarela / imunologia; Vacina contra Febre Amarela / imunologia; Imuniza??o Secund?ria
• Document Type: Journal article
• Language: English

Description

Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais, Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, Bio-Manguinhos/FIOCRUZ, PROEP/ CPqRR/FIOCRUZ, Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico?CNPq (grant nos. 444417/2014-1 and 458134/2014-7), and Programa Nacional de Imuniza??es, Secretaria de Vigil?ncia em Sa?de?Minist?rio da Sa?de, Brazil (grant no. TC 277/2013). O.A.M.-F., A.T.-C., and L.R.A. received research fellowships from CNPq.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

Secretaria Municipal de Sa?de. Belo Horizonte, MG, Brasil.

Secretaria do Estado de Sa?de de Minas Gerais. Belo Horizonte, MG, Brasil.

Funda??o Oswaldo Cruz. Escola Nacional de Sa?de P?blica. Rio de Janeiro, RJ, Brazil.

Funda??o Oswaldo Cruz. Instituto de Tecnologia em Imunobiol?gicos Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.

Funda??o Oswaldo Cruz. Instituto de Tecnologia em Imunobiol?gicos Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.

Funda??o Oswaldo Cruz. Instituto de Tecnologia em Imunobiol?gicos Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.

Funda??o Oswaldo Cruz. Instituto de Tecnologia em Imunobiol?gicos Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.

Funda??o Oswaldo Cruz. Instituto de Tecnologia em Imunobiol?gicos Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.

Universidade Federal de Alfenas. Alfenas, MG, Brazil.

Universidade de Bras?lia. Bras?lia, DF, Brazil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Bras?lia, DF, Brasil.

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Bras?lia, DF, Brasil.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

Funda??o Oswaldo Cruz. Instituto Ren? Rachou. Belo Horizonte, MG, Brazil.

We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine?specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-?+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-?+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF?specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.