Autor(es):
Crespo-L?pez, Maria Elena ; Soares, Ericks Sousa ; Macchi, Barbarella de Matos ; Santos-Sacramento, Leticia ; Takeda, Priscila Yuki ; Lopes-Ara?jo, Amanda ; Paraense, Ricardo Sousa de Oliveira ; Souza-Monteiro, Jos? Rog?rio ; Oliveira, Marcus Augusto de ; Luz, Diandra Ara?jo ; Maia, Cristiane do Socorro Ferraz ; Rogez, Herv? ; Lima, Marcelo de Oliveira ; Pereira, Jo?o Paulo ; Oliveira, Diomar Cavalcante ; Burbano, Rommel Rodrigues ; Lima, Rafael Rodrigues ; Nascimento, Jos? Luiz Martins do ; Arrifano, Gabriela de Paula
Data: 2019
Origem: Oasisbr
Assunto(s): Euterpe / metabolismo; Euterpe / efeitos dos f?rmacos; Ingest?o de Alimentos; Sucos de Frutas e Vegetais; Antioxidantes; Sistema Nervoso Central / efeitos dos f?rmacos; Intoxica??o do Sistema Nervoso por Merc?rio; Compostos de Metilmerc?rio / toxicidade; Envelhecimento / metabolismo
Descrição
Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq, grant numbers 27724/2018-2 and 307564/2017-7), Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES, grant numbers 88887.200500/2018-00 and 88881.172137/2018-01), and Pr?-reitoria de Pesquisa da Universidade Federal do Par? (PROPESP?UFPA, s/n)
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil / Federal University of Santa Catarina. Center of Biological Sciences. Laboratory of Neurochemical Investigation. Florian?polis, SC, Brazil.
Federal University of Par?. Laboratory of Molecular and Cellular Neurochemistry. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil / University of Oxford. Department of Pharmacology. Laboratory of Experimental Neuropathology. Oxford, OX. UK.
Federal University of Par?. Laboratory of Pharmacology of Inflammation and Behavior. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Pharmacology of Inflammation and Behavior. Bel?m, PA, Brazil.
Federal University of Par?. Centre for Valorisation of Amazonian Bioactive Compounds. Bel?m, PA, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ophir Loyola Hospital. Laboratory of Molecular Biology. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Functional and Structural Biology. Bel?m, PA, Brazil.
Federal University of Par?. Laboratory of Molecular and Cellular Neurochemistry. Bel?m, PA, Brazil
Federal University of Par?. Laboratory of Molecular Pharmacology. Bel?m, PA, Brazil / University of Oxford. Department of Pharmacology. Laboratory of Experimental Neuropathology. Oxford, UK.
Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 ?L/g) against MeHg i.p. exposure (2.5 mg/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical (lipid peroxidation and nitrite levels), aging-related (telomerase reverse transcriptase (TERT) mRNA expression) and toxicokinetic (MeHg content) parameters in mice. Both the pole and rotarod tests were the most sensitive tests accompanied by increased lipid peroxidation and nitrite levels in brains. MeHg reduced TERT mRNA about 50% demonstrating a strong pro-aging effect. The EO intake, similar to that of human populations, prevented all alterations, without changing the mercury content, but avoiding neurotoxicity and premature aging of the Central Nervous System (CNS). Contrary to the hypothesis found in the literature on the possible chelating properties of Amazonian fruits consumption, the effect of EO would be essentially pharmacodynamics, and possible mechanisms are discussed. Our data already support the regular consumption of EO as an excellent option for exposed Amazonian populations to have additional protection against MeHg intoxication
