Author(s):
Ara?jo, Thessika Hialla Almeida ; Barreto, Fernanda Khouri ; Menezes, Aline D?rea Luz ; Lima, Clayton Pereira Silva de ; Oliveira, Rodrigo Santos de ; Lemos, Poliana da Silva ; Galv?o-Castro, Bernardo ; Kashima, Simone ; Farre, Lourdes ; Bittencourt, Achilea Lisboa ; Carvalho, Edgar Marcelino de ; Santos, Luciane Amorim ; Rego, Filipe Ferreira de Almeida ; Mota-Miranda, Aline Cristina Andrade ; Nunes, M?rcio Roberto Teixeira ; Alc?ntara, Luiz Carlos J?nior
Date: 2020
Origin: Oasisbr
Subject(s): V?rus Linfotr?pico T Tipo 1 Humano / isolamento & purifica??o; V?rus Linfotr?pico T Tipo 1 Humano / patogenicidade; Genoma Viral; Genoma / gen?tica; Nucleot?deos / gen?tica; Intera??es Hospedeiro-Pat?geno
Description
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brazil / Escola Bahiana de Medicina e Sa?de P?blica. Salvador, BA, Brazil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brazil / Universidade Federal da Bahia, Salvador, BA, Brazil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Escola Bahiana de Medicina e Sa?de P?blica. Salvador, BA, Brazil.
Funda??o Hemocentro de Ribeir?o Preto. S?o Paulo, SP, Brazil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brazil / Bellvitge Biomedical Research Institute. Catalan Institute of Oncology. Barcelona, Spain.
Universidade Federal da Bahia. Salvador, BA, Brazil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brazil / Universidade Federal da Bahia. Salvador, BA, Brazil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brazil / Escola Bahiana de Medicina e Sa?de P?blica. Salvador, BA, Brazil.
Universidade Cat?lica do Salvador. Salvador, BA, Brazil.
Universidade Federal da Bahia. Salvador, BA, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Funda??o Oswaldo Cruz. Instituto Gon?alo Moniz. Salvador, BA, Brazil.
The HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete genomes publicly available, about 0.12 complete genomes per 10,000 infected individuals and the databases have a major deficiency of sequences information. This study generated and characterized 31 HTLV-1 complete genomes sequences derived from individuals with Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM), Adult T-cell leukemia/lymphoma (ATL), infective dermatitis associated to HTLV-1 (IDH) and asymptomatic patients. These sequences are associated to clinical and epidemiological information about the patients. The sequencing data generated on Ion Torrent PGM platform were assembled and mapped against the reference HTLV-1 genome. These sequences were genotyped as Cosmopolitan subtype, Transcontinental subgroup. We identified the variants in the coding regions of the genome of the different clinical profiles, however, no statistical relation was detected. This study contributed to increase of HTLV-1 complete genomes in the world. Furthermore, to better investigate the contribution of HTLV-1 mutations for the disease outcome it is necessary to evaluate the interaction of the viral genome and characteristics of the human host.
