Autor(es):
Moreira-Nunes, Caroline de F?tima Aquino ; Martins, Cl?udia Nazar? de Souza Almeida Titan ; Feio, Danielle ; Lima, Isamu Komatsu ; Lamar?o, Leticia Martins ; Souza, Carolina Rosal Teixeira de ; Costa, Igor Brasil ; Mau?s, Jersey Heitor da Silva ; Soares, Paulo Cardoso ; Assump??o, Paulo Pimentel de ; Burbano, Rommel M?rio Rodr?gues
Data: 2021
Origem: Oasisbr
Assunto(s): Neoplasias G?stricas; Herpesvirus Humano 4 / patogenicidade; Biomarcadores Tumorais; Prote?na 2 Ligante de Morte Celular Programada 1
Descrição
Funding: This study was supported by the National Council of Technological and Scientific Development (CNPq) and PROPESP/UFPA .
Ophir Loyola Hospital. Department of Clinical Medicine. Laboratory of Molecular Biology. Bel?m, PA, Brazil / Federal University of Cear?. Department of Medicine, Drug Research and Development Center. Laboratory of Pharmacogenetics. Fortaleza, CE, Brazil.
Ophir Loyola Hospital. Department of Clinical Medicine. Laboratory of Molecular Biology. Bel?m, PA, Brazil.
Ophir Loyola Hospital. Department of Clinical Medicine. Laboratory of Molecular Biology. Bel?m, PA, Brazil.
Ophir Loyola Hospital. Department of Clinical Medicine. Laboratory of Molecular Biology. Bel?m, PA, Brazil.
Foundation Center for Hemotherapy and Hematology of Par?. Department of Sorology. Bel?m, PA, Brazil.
Federal University of Par?. Biological Science Institute. Human Cytogenetics Laboratory. Bel?m, PA, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
University of Campinas. Department of Medicine. Laboratory of Molecular and Cell Biology. Hematology and Transfusion Medicine Center. Campinas, SP, Brazil.
Ophir Loyola Hospital. Department of Clinical Medicine. Laboratory of Molecular Biology. Bel?m, PA, Brazil
Federal University of Par?. Department of Biological Sciences. Oncology Research Center. Bel?m, PA, Brazil.
Ophir Loyola Hospital. Department of Clinical Medicine. Laboratory of Molecular Biology. Bel?m, PA, Brazil / Federal University of Par?. Department of Biological Sciences. Oncology Research Center. Bel?m, PA, Brazil.
Abstract: Gastric cancer (GC) is a worldwide health problem, making it one of the most common types of cancer, in fifth place of all tumor types, and the third highest cause of cancer deaths in the world. There is a subgroup of GC that consists of tumors infected with the Epstein?Barr virus (EBV) and is characterized mainly by the overexpression of programmed cell death protein-ligand-1 (PD-L1). In the present study, we present histopathological and survival data of a thousand GC patients, associated with EBV status and PD-L1 expression. Of the thousand tumors analyzed, 190 were EBV-positive and the vast majority (86.8%) had a high relative expression of mRNA and PD-L1 protein (p < 0.0001) in relation to non-neoplastic control. On the other hand, in EBV-negative samples, the majority had a low PD-L1 expression of RNA and protein (p < 0.0001). In the Kaplan?Meier analysis, the probability of survival and increased overall survival of EBV-positive GC patients was impacted by the PD-L1 overexpression (p < 0.0001 and p = 0.004, respectively). However, the PD-L1 low expression was correlated with low overall survival in those patients. Patients with GC positive for EBV, presenting PD-L1 overexpression can benefit from immunotherapy treatments and performing the quantification of PD-L1 in gastric neoplasms should be adopted as routine.
