Autor(es):
Meurer, Igor Rosa ; Silva, Marcio Roberto ; Silva, Marcos Vin?cius Ferreira ; Dur?, Ana ?ris de Lima ; Adelino, Talita ?mile Ribeiro ; Costa, Alana Vitor Barbosa da ; Vanelli, Chislene Pereira ; Guimar?es, Ricardo Jos? de Paula Souza e ; Rozental, Tatiana ; Lemos, Elba Regina Sampaio de ; Corr?a, Jos? Ot?vio do Amaral
Data: 2021
Origem: Oasisbr
Assunto(s): Coxiella burnetii / isolamento & purifica??o; Febre Q / veterin?ria; Cria??o de Animais Dom?sticos; T?cnica Indireta de Fluoresc?ncia para Anticorpo / m?todos; Rea??o em Cadeia da Polimerase em Tempo Real / m?todos; Estudos Soroepidemiol?gicos; Minas Gerais (MG); Zoonoses Bacterianas
Descrição
Federal University of Juiz de Fora. Faculty of Pharmacy. Juiz de Fora, MG, Brazil.
Embrapa Dairy Cattle. Juiz de Fora, MG, Brazil
Ezequiel Dias Foundation. Central Public Health Laboratory of the State of Minas Gerais. Belo Horizonte, MG, Brazil.
Ezequiel Dias Foundation. Central Public Health Laboratory of the State of Minas Gerais. Belo Horizonte, MG, Brazil.
Ezequiel Dias Foundation. Central Public Health Laboratory of the State of Minas Gerais. Belo Horizonte, MG, Brazil.
Ezequiel Dias Foundation. Central Public Health Laboratory of the State of Minas Gerais. Belo Horizonte, MG, Brazil.
Suprema. Faculty of Medical Sciences and Health of Juiz de Fora. Juiz de Fora, MG, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Laborat?rio de Geoprocessamento. Ananindeua, PA, Brasil.
Oswaldo Cruz Foundation. Laboratory of Hantaviruses and Rickettsiosis. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Laboratory of Hantaviruses and Rickettsiosis. Rio de Janeiro, RJ, Brazil.
Federal University of Juiz de Fora. Faculty of Pharmacy. Juiz de Fora, MG, Brazil.
Background: Q fever is among the top 13 global priority zoonoses, however, it is still neglected and under-reported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state. Methods: Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Risk factors for infections and spatial clusters for both C. burnetii-seropositive individuals and livestock concentration were evaluated. Results: We found that 21 samples (4.8%; 95% CI 3.0 to 7.2%) were reactive for at least one class of anti-C. burnetii antibodies (titer of ?64), with rural residence (p=0.036) being a risk factor. Also, two spatial clusters of seropositivity were found within a significant area by Scan, and a probable relationship between the Scan result and the livestock concentration by area was found. Conclusions: Seropositive individuals were associated with rural residence, with a likely relationship with the livestock concentration. Thus, this study establishes baseline figures for C. burnetii seroprevalence in humans in a state of Brazil, allowing the monitoring of trends and setting of control targets, as well as more representative longitudinal and risk analysis studies.
