Autor(es): Afsar, A ; Martins, F ; Bruno M P M Oliveira ; Pinto, AA
Data: 2021
Identificador Persistente: https://hdl.handle.net/10216/137611
Origem: Repositório Aberto da Universidade do Porto
Assunto(s): Ciências da Saúde, Ciências médicas e da saúde; Health sciences, Medical and Health sciences
We make two fits of an ODE system with 5 equations that model immune response by CD4 + T cells with the presence of regulatory T cells (Tregs). We fit the simulations to data regarding gp61 and NP309 epitopes from mice infected with lymphocytic choriomeningitis virus LCMV. We optimized parameters relating to: the T cell maximum growth rate; the T cell capacity; the T cell homeostatic level; and the ending time of the immune activation phase after infection. We quantitatively and qualitatively compare the obtained results with previous fits in the literature using different ODE models and we show that we are able to calibrate the model and obtain good fits describing the data. (c) 2021, Springer Nature Switzerland AG.
