Balancing cell polarity PARts through dephosphorylation

• Autor(es): Barros-Carvalho, A ; Morais-de-Sá, E
• Data: 2022
• Identificador Persistente: https://hdl.handle.net/10216/165545
• Origem: Repositório Aberto da Universidade do Porto
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

How cells spatially organize their plasma membrane, cytoskeleton, and cytoplasm remains a central question for cell biologists. In this issue of JCB, Calvi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202201048) identify PP1 phosphatases as key regulators of C. elegans anterior–posterior polarity, by counterbalancing aPKC-mediated phosphorylation of PAR-2.