Author(s):
Martin Martins, J ; Alves, J ; Trinca, A ; Grima, B ; Vale, S ; Vasconcelos, T ; Riso, N ; Vaz Riscado, M ; Charneco da Costa, J
Date: 2002
Persistent ID: http://hdl.handle.net/10400.17/1797
Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
Subject(s): HCC END; Hormona Adrenocorticotrópica; Sulfato de Desidroepiandrosterona; Lateralidade Funcional; Cérebro; Hepatite C; Hidrocortisona; Lúpus Eritematoso Sistémico; MMPI; Sistemas Neurossecretores; Personalidade; Projectos Piloto; Prolactina
Description
Development of some immune-mediated disorders may depend on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To explore neuropsychologic mechanisms in relation to the abnormal endocrine reactivity in patients with systemic lupus erythematosus (SLE) and chronic hepatitis C (CHC) we used the corticotropin releasing hormone (CRH) test, the Minnesota Multiphasic Personality Inventory (MMPI), and the Edinburgh Inventory of Manual Preference Inventory (EIMP). Compared to controls, the adrenocorticotrophic hormone (ACTH) response to CRH was reduced in CHC, while SLE presented reduced baseline dehydroepiandrosterone sulfate levels; higher neurotic scores were found in SLE and higher behavior deviant scores in CHC. Peak ACTH levels were a significant factor for the MMPI profile variability, while the manual preference score was a significant factor for the ACTH response. Personality and manual preference contribute to neuroendocrine abnormalities. Different behavioral and neuroimmunoendocrine models emerge for these disorders.
